STK38 - serine/threonine kinase 38 Gene

Homo sapiens

Also known as NDR; NDR1

Gene ID: 11329 | Gene type: protein coding

About STK38

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,493,892-36,547,479 (from NCBI)

This gene has 1 transcript (splice variant), 250 orthologues and 1 paralogue. Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues.

Summary

This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by Other upstream kinases. This protein has been shown to function in the cell cycle and Apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

STK38 Products(2)

mRNA	Protein	Name
NM_001305102.2	NP_001292031.1	serine/threonine-protein kinase 38
NM_007271.4	NP_009202.1	serine/threonine-protein kinase 38

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12493777	GOA
enables UFM1-modified protein reader activity	IDA IDA: Inferred from direct assay	32537488	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	32537488	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12493777	GOA
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	17906693	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9774336	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12493777	GOA
enables ubiquitin-like protein reader activity	IDA IDA: Inferred from direct assay	32537488	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	32537488	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	32537488	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12493777	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	17906693	GOA
involved in protein modification process	IDA IDA: Inferred from direct assay	7761441	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12493777	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17906693	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12493777	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	32537488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK38 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 38

NDR1 protein kinase

STK38 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STK38	Q15208	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	STK38	Q15208	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	STK38	Q15208	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	STK38	Q15208	MOB2	Homo sapiens	Q70IA6	Anti Tag CoIP	25852190
Intra	STK38	Q15208	MOB2	Homo sapiens	Q70IA6	Pull Down	32707033
Intra	STK38	Q15208	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	STK38	Q15208	NCK1	Homo sapiens	P16333	Anti Bait CoIP	31980649
Intra	STK38	Q15208	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	17620599
Intra	STK38	Q15208	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	15197186
Intra	STK38	Q15208	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	25852190
Cross	STK38	Q15208	S100B	Bos taurus	P02638	NMR	14661952
Cross	STK38	Q15208	S100B	Bos taurus	P02638	Affinity Chrom	9774336

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10211	Tanespimycin		99.01%	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13938	STK38 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13939	STK38L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STK38	VGNC	VGNC:46919
Felis catus	STK38	VGNC	VGNC:65786
Mus musculus	STK38	MGD	MGI:2442572
Rattus norvegicus	STK38	RGD	RGD:1309455
Macaca mulatta	STK38	VGNC	VGNC:78155
Bos taurus	STK38	VGNC	VGNC:35399
Others	STK38	NCBI

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