2. Gene
  3. TSPAN14 - tetraspanin 14 Gene

TSPAN14 - tetraspanin 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TM4SF14; DC-TM4F2; tspan-14

Gene ID: 81619 | Gene type: protein coding

About TSPAN14

This gene has 10 transcripts (splice variants), 199 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 22.8), placenta (RPKM 20.4) and 25 other tissues.

Summary

Enables Enzyme binding activity. Involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TSPAN14 Products(9)

mRNA Protein Name
NM_001128309.3 NP_001121781.1 tetraspanin-14 isoform 2
NM_001351266.2 NP_001338195.1 tetraspanin-14 isoform 1
NM_001351267.4 NP_001338196.1 tetraspanin-14 isoform 1
NM_001351268.2 NP_001338197.1 tetraspanin-14 isoform 1
NM_001351269.2 NP_001338198.1 tetraspanin-14 isoform 1
NM_001351270.2 NP_001338199.1 tetraspanin-14 isoform 1
NM_001351271.2 NP_001338200.1 tetraspanin-14 isoform 1
NM_001351272.2 NP_001338201.1 tetraspanin-14 isoform 1
NM_030927.4 NP_112189.2 tetraspanin-14 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23091066 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23091066 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23091066 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23035126 GOA
involved in protein maturation IMP
IMP: Inferred from mutant phenotype
23091066 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
23091066 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN14 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (16 - 259)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

tetraspanin-14

tetraspanin similar to TM4SF9

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C2

NPC2

Niemann-Pick Disease Type C2

Niemann-Pick C2 Disease

Niemann-Pick Disease C2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15162 TSPAN14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TSPAN14 VGNC VGNC:47914
Rattus norvegicus TSPAN14 RGD RGD:1305714
Mus musculus TSPAN14 MGD MGI:1196325
Bos taurus TSPAN14 VGNC VGNC:36429
Macaca mulatta TSPAN14 VGNC VGNC:79386