Grm7 - glutamate metabotropic receptor 7 Gene

Rattus norvegicus

Gene ID: 81672 | Gene type: protein coding

About Grm7

Primary_assembly 4: 143,731,259-144,612,344 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 7 phenotypes. Restricted expression toward (RPKM 123.2).

Summary

Enables several functions, including PDZ domain binding activity; Calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; rough endoplasmic reticulum; and synaptic membrane. Part of protein-containing complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 Products(1)

mRNA	Protein	Name
NM_031040.1	NP_112302.1	metabotropic glutamate receptor 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	11007882	RGD
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IDA IDA: Inferred from direct assay	11825890	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	21855531	RGD
enables calmodulin binding	IPI IPI: Inferred from physical interaction	12021391	RGD
enables glutamate binding	IDA IDA: Inferred from direct assay	11825890	RGD
enables group III metabotropic glutamate receptor activity	IDA IDA: Inferred from direct assay	12692128	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17620729	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11891216	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	11825890	RGD
involved in negative regulation of glutamate secretion	IDA IDA: Inferred from direct assay	11825890	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	26621121	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	9295396	RGD
located in asymmetric synapse	IDA IDA: Inferred from direct assay	9300765	RGD
located in axon	IDA IDA: Inferred from direct assay	9300765	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	11825890	RGD
located in cell surface	IDA IDA: Inferred from direct assay	16890965	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9300765	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	12823458	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8604049	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8929965	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	8764662	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	8764662	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	9295396	RGD
is active in presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	35511883	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	8604049	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	9300765	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11007882	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	12823458	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm7 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tmC_mGluR7

0
200
400
600
800
922 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 7

glutamate receptor, metabotropic 7	mGluR7
metabotropic glutamate receptor mGluR7	metabotropic glutamate receptor subtype 7b

Grm7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grm7	P35400	Pick1	Rattus norvegicus	Q9EP80	Pull Down	11891216
Intra	Grm7	P35400	Pick1	Rattus norvegicus	Q9EP80	Anti Tag CoIP	11007882
Intra	Grm7	P35400	Pick1	Rattus norvegicus	Q9EP80	Y2H Array	11007882
Intra	Grm7	P35400	Pick1	Rattus norvegicus	Q9EP80	Y2H	11891216
Intra	Grm7	P35400	Pick1	Rattus norvegicus	Q9EP80	Pull Down	11007882
Intra	Grm7	P35400	Ppp1cc	Rattus norvegicus	P63088	Y2H	14519764
Intra	Grm7	P35400	Grip1	Rattus norvegicus	P97879	Pull Down	11891216
Intra	Grm7	P35400	Grip1	Rattus norvegicus	P97879	Imaging	11891216

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05837	GRM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05838	Grm7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05839	Grm7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm7	NCBI	NCBI:2917

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