Nfkb1 - nuclear factor kappa B subunit 1 Gene

Rattus norvegicus

Also known as EBP-1; NF-kB

Gene ID: 81736 | Gene type: protein coding

About Nfkb1

Primary_assembly 2: 224,016,214-224,110,404 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 44 phenotypes. Biased expression in Spleen (RPKM 254.), Lung (RPKM 29.4) and 9 other tissues.

Summary

Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb1 Products(1)

mRNA	Protein	Name
NM_001276711.1	NP_001263640.1	nuclear factor NF-kappa-B p105 subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19414010	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	9718198	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	16135962	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10854252	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11313306	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10854252	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16135962	RGD
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	9585425	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	14576180	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IDA IDA: Inferred from direct assay	11520908	RGD
involved in cellular response to carbohydrate stimulus	IDA IDA: Inferred from direct assay	11146106	RGD
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19414010	RGD
involved in cellular response to diterpene	IDA IDA: Inferred from direct assay	19765580	RGD
involved in cellular response to glucoside	IDA IDA: Inferred from direct assay	16842873	RGD
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	17726227	RGD
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	16842873	RGD
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19414010	RGD
involved in cellular response to peptide	IDA IDA: Inferred from direct assay	19765580	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	18625500	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	9718198	RGD
involved in leukocyte migration involved in inflammatory response	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16354757	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12742080	RGD
involved in response to bacterium	IEP IEP: Inferred from expression pattern	15777838	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	17418555	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	20211236	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	12193536	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	29091898	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	9343439	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfkb1 Protein Structure

RHD-n_NFkB1

IPT_NFkappaB

ANK

Ank_2

ANK

Ank_2

ANK

Ank_2

ANK

Death_NFkB1_p105

0
200
400
600
800
973 a.a.

Protein Preferred Names

Protein Names

nuclear factor NF-kappa-B p105 subunit

DNA-binding factor KBF1	nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133987	AP-1/NF-κB activation inhibitor 1	Inhibitor	99.03%	Unkown
HY-49444	EN450	Degrader	99.28%	Unkown
HY-152177	JS6		99.67%	Unkown
HY-N0001S	(±)-Epicatechin-13C3		/	Unkown
HY-N3532	Cannabisin F	Modulator	/	Unkown
HY-RS09254	NFKB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09255	Nfkb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09256	Nfkb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkb1	NCBI	NCBI:4790

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