2. Gene
  3. MAD2L2 - mitotic arrest deficient 2 like 2 Gene

MAD2L2 - mitotic arrest deficient 2 like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as REV7; FANCV; MAD2B; POLZ2

Gene ID: 10459 | Gene type: protein coding

About MAD2L2

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,674,480-11,691,830 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 22.7), bone marrow (RPKM 15.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

MAD2L2 Products(2)

mRNA Protein Name
NM_001127325.2 NP_001120797.1 mitotic spindle assembly checkpoint protein MAD2B
NM_006341.4 NP_006332.3 mitotic spindle assembly checkpoint protein MAD2B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables JUN kinase binding IDA
IDA: Inferred from direct assay
17296730 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
19443654 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10527948 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response, signal transduction resulting in transcription IDA
IDA: Inferred from direct assay
17296730 GOA
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
19443654 GOA
involved in double-strand break repair IGI
IGI: Inferred from genetic interaction
15988022 GOA
involved in error-prone translesion synthesis IDA
IDA: Inferred from direct assay
24449906 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19443654 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19443654 GOA
involved in negative regulation of cell-cell adhesion mediated by cadherin IMP
IMP: Inferred from mutant phenotype
19443654 GOA
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
29656893 GOA
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
19443654 GOA
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
11459826 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19443654 GOA
involved in negative regulation of transcription by competitive promoter binding IMP
IMP: Inferred from mutant phenotype
19443654 GOA
involved in negative regulation of transcription regulatory region DNA binding IMP
IMP: Inferred from mutant phenotype
19443654 GOA
involved in negative regulation of ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11459826 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17296730 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of isotype switching IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17296730 GOA
involved in regulation of cell growth IGI
IGI: Inferred from genetic interaction
15988022 GOA
Cellular Component GO Annotation Evidence Reference Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
11459825 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17541814 GOA
located in spindle IDA
IDA: Inferred from direct assay
21063390 GOA
part of zeta DNA polymerase complex IDA
IDA: Inferred from direct assay
20164194 GOA
part of zeta DNA polymerase complex IPI
IPI: Inferred from physical interaction
24449906 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAD2L2 Protein Structure

HORMA

HORMA: HORMA domain (14 - 153)

  • 0
  • 100
  • 211 a.a.
Protein Preferred Names Protein Names

mitotic spindle assembly checkpoint protein MAD2B

MAD2 (mitotic arrest deficient, yeast, homolog)-like 2

MAD2L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAD2L2 Q9UI95 ZNF511 Homo sapiens Q8NB15
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 ZNF511 Homo sapiens Q8NB15
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 SFI1 Homo sapiens A8K8P3-4
Y2H Prey Pooling
25416956
Intra
MAD2L2 Q9UI95 SFI1 Homo sapiens A8K8P3-4
Y2H Array
25416956
Intra
MAD2L2 Q9UI95 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 CAMK2B Homo sapiens Q13554
Validated Y2H
25416956
Intra
MAD2L2 Q9UI95 CAMK2B Homo sapiens Q13554
Y2H Array
25416956
Intra
MAD2L2 Q9UI95 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
MAD2L2 Q9UI95 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
MAD2L2 Q9UI95 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
MAD2L2 Q9UI95 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 CIMIP1 Homo sapiens Q9H1P6
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 CIMIP1 Homo sapiens Q9H1P6
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 DEPDC5 Homo sapiens O75140-2
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 DEPDC5 Homo sapiens O75140-2
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 MBD3L1 Homo sapiens Q8WWY6
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 MBD3L1 Homo sapiens Q8WWY6
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 PRR5L Homo sapiens Q6MZQ0
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 PRR5L Homo sapiens Q6MZQ0
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 PPM1B Homo sapiens O75688-3
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 PPM1B Homo sapiens O75688-3
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 FTO Homo sapiens Q9C0B1-2
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 FTO Homo sapiens Q9C0B1-2
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 FAM217B Homo sapiens Q9NTX9
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 FAM217B Homo sapiens Q9NTX9
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 SHLD3 Homo sapiens Q6ZNX1
Anti Tag CoIP
29656893
Intra
MAD2L2 Q9UI95 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 CHAMP1 Homo sapiens Q96JM3
Anti Tag CoIP
29789392
Intra
MAD2L2 Q9UI95 CHAMP1 Homo sapiens Q96JM3
Anti Tag CoIP
29656893
Intra
MAD2L2 Q9UI95 CHAMP1 Homo sapiens Q96JM3
Anti Tag CoIP
21063390
Intra
MAD2L2 Q9UI95 CHAMP1 Homo sapiens Q96JM3
Anti Tag CoIP
26496610
Intra
MAD2L2 Q9UI95 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 REV3L Homo sapiens O60673
NMR
22828282
Intra
MAD2L2 Q9UI95 REV3L Homo sapiens O60673
ITC
22828282
Intra
MAD2L2 Q9UI95 REV3L Homo sapiens O60673
GMS
22828282
Intra
MAD2L2 Q9UI95 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra
MAD2L2 Q9UI95 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
MAD2L2 Q9UI95 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
MAD2L2 Q9UI95 CDC20 Homo sapiens Q12834
Pull Down
17719540
Intra
MAD2L2 Q9UI95 CDC20 Homo sapiens Q12834
Anti Tag CoIP
17719540
Intra
MAD2L2 Q9UI95 ZNF558 Homo sapiens Q96NG5
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 ZNF558 Homo sapiens Q96NG5
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 THAP6 Homo sapiens Q8TBB0
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 THAP6 Homo sapiens Q8TBB0
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 KCTD9 Homo sapiens Q7L273
Validated Y2H
25416956
Cross
MAD2L2 Q9UI95 sctE Shigella flexneri P18011
Y2H
17719540
Cross
MAD2L2 Q9UI95 sctE Shigella flexneri P18011
Anti Tag CoIP
17719540
Cross
MAD2L2 Q9UI95 sctE Shigella flexneri P18011
IF
17719540
Cross
MAD2L2 Q9UI95 sctE Shigella flexneri P18011
Pull Down
17719540
Intra
MAD2L2 Q9UI95 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
MAD2L2 Q9UI95 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
MAD2L2 Q9UI95 FZR1 Homo sapiens Q9UM11
Anti Tag CoIP
17719540
Intra
MAD2L2 Q9UI95 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra
MAD2L2 Q9UI95 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
MAD2L2 Q9UI95 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
MAD2L2 Q9UI95 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 ADAM9 Homo sapiens Q13443
Pull Down
10527948
Intra
MAD2L2 Q9UI95 ADAM9 Homo sapiens Q13443
Y2H
10531379
Intra
MAD2L2 Q9UI95 ADAM9 Homo sapiens Q13443
Y2H
10527948
Intra
MAD2L2 Q9UI95 RAB11FIP4 Homo sapiens Q86YS3
Y2H Prey Pooling
32296183
Intra
MAD2L2 Q9UI95 RAB11FIP4 Homo sapiens Q86YS3
Y2H Array
32296183
Intra
MAD2L2 Q9UI95 CDC27 Homo sapiens P30260
Anti Bait CoIP
17719540
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group V

Fanconi Anemia Complementation Group V

FANCV
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07951 MAD2L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAD2L2 MGD MGI:1919140
Rattus norvegicus MAD2L2 RGD RGD:1307499
Macaca mulatta MAD2L2 VGNC VGNC:74472
Felis catus MAD2L2 VGNC VGNC:68126
Bos taurus MAD2L2 VGNC VGNC:31132
Canis familiaris MAD2L2 VGNC VGNC:52216