2. Gene
  3. AGPAT4 - 1-acylglycerol-3-phosphate O-acyltransferase 4 Gene

AGPAT4 - 1-acylglycerol-3-phosphate O-acyltransferase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LPAAT4; LPLAT4; 1-AGPAT4; dJ473J16.2; LPAAT-delta

Gene ID: 56895 | Gene type: protein coding

About AGPAT4

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:161,129,967-161,274,061 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 4 paralogues. Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues.

Summary

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

AGPAT4 Products(1)

mRNA Protein Name
NM_020133.3 NP_064518.1 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT4 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (87 - 230)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1-AGP acyltransferase 4

AGPAT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra AGPAT4 Q9NRZ5 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FCGR2A Homo sapiens P12318-2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 FCGR2A Homo sapiens P12318-2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP12B Homo sapiens A6NM10-2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP12B Homo sapiens A6NM10-2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FCRL3 Homo sapiens Q96P31-6
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FCRL3 Homo sapiens Q96P31-6
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fetal Akinesia Deformation Sequence 4

FADS4

Fetal Akinesia Deformation Sequence Syndrome 4

Akinesia, Fetal, Deformation Sequence, Type 4
Complete Generalized Lipodystrophy
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00459 AGPAT4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AGPAT4 VGNC VGNC:59687
Canis familiaris AGPAT4 VGNC VGNC:37713
Bos taurus AGPAT4 VGNC VGNC:25737
Macaca mulatta AGPAT4 VGNC VGNC:69654
Mus musculus AGPAT4 MGD MGI:1915512
Rattus norvegicus AGPAT4 RGD RGD:619916