SYMPK - symplekin scaffold protein Gene

Homo sapiens

Also known as SPK; SYM; Pta1

Gene ID: 8189 | Gene type: protein coding

About SYMPK

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,815,410-45,863,147 (from NCBI)

This gene has 18 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in testis (RPKM 32.3), spleen (RPKM 15.5) and 25 other tissues.

Summary

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]

SYMPK Products(1)

mRNA	Protein	Name
NM_004819.3	NP_004810.2	symplekin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14707147	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	29158257	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8769423	GOA
located in nuclear stress granule	IDA IDA: Inferred from direct assay	14707147	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	8769423	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYMPK Protein Structure

DUF3453

Symplekin_C

0
200
400
600
800
1000
1200
1274 a.a.

Protein Preferred Names

Protein Names

symplekin

SYMPK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SYMPK	Q92797	CPSF2	Homo sapiens	Q9P2I0	Anti Bait CoIP	18288197
Intra	SYMPK	Q92797	CPSF2	Homo sapiens	Q9P2I0	Anti Tag CoIP	18688255
Intra	SYMPK	Q92797	CPSF2	Homo sapiens	Q9P2I0	GMS	35177536
Intra	SYMPK	Q92797	CPSF2	Homo sapiens	Q9P2I0	Anti Tag CoIP	26496610
Intra	SYMPK	Q92797	SSU72	Homo sapiens	Q9NP77-1	X-Ray Diffraction	20861839
Intra	SYMPK	Q92797	SSU72	Homo sapiens	Q9NP77-1	GMS	20861839
Intra	SYMPK	Q92797	CSTF2	Homo sapiens	P33240	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14078	SYMPK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SYMPK	VGNC	VGNC:47022
Felis catus	SYMPK	VGNC	VGNC:65877
Bos taurus	SYMPK	VGNC	VGNC:35514
Rattus norvegicus	SYMPK	RGD	RGD:1306735
Macaca mulatta	SYMPK	VGNC	VGNC:78195
Mus musculus	SYMPK	MGD	MGI:1915438

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