2. Gene
  3. CPSF2 - cleavage and polyadenylation specific factor 2 Gene

CPSF2 - cleavage and polyadenylation specific factor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CPSF100

Gene ID: 53981 | Gene type: protein coding

About CPSF2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,121,969-92,172,145 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 13.0), thyroid (RPKM 12.9) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in membrane. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]

CPSF2 Products(4)

mRNA Protein Name
NM_001322270.2 NP_001309199.1 cleavage and polyadenylation specificity factor subunit 2 isoform 2
NM_001322271.2 NP_001309200.1 cleavage and polyadenylation specificity factor subunit 2 isoform 3
NM_001322272.2 NP_001309201.1 cleavage and polyadenylation specificity factor subunit 2 isoform 1
NM_017437.3 NP_059133.1 cleavage and polyadenylation specificity factor subunit 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18288197 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA 3'-end processing by stem-loop binding and cleavage IDA
IDA: Inferred from direct assay
18688255 GOA
Cellular Component GO Annotation Evidence Reference Source
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
18305108 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF2 Protein Structure

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (17 - 181)

Beta-Casp

Beta-Casp: Beta-Casp domain (243 - 367)

RMMBL

RMMBL: Zn-dependent metallo-hydrolase RNA specificity domain (527 - 569)

CPSF100_C

CPSF100_C: Cleavage and polyadenylation factor 2 C-terminal (608 - 779)

  • 0
  • 200
  • 400
  • 600
  • 782 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 2

CPSF 100 kDa subunit

CPSF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CPSF2 Q9P2I0 SYMPK Homo sapiens Q92797
GMS
35177536
Intra
CPSF2 Q9P2I0 SYMPK Homo sapiens Q92797
Anti Tag CoIP
18688255
Intra
CPSF2 Q9P2I0 SYMPK Homo sapiens Q92797
Anti Tag CoIP
33961781
Intra
CPSF2 Q9P2I0 CSTF2 Homo sapiens P33240
Anti Tag CoIP
18688255
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03117 CPSF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPSF2 VGNC VGNC:61140
Canis familiaris CPSF2 VGNC VGNC:39574
Bos taurus CPSF2 VGNC VGNC:27671
Macaca mulatta CPSF2 VGNC VGNC:71473
Mus musculus CPSF2 MGD MGI:1861601
Rattus norvegicus CPSF2 RGD RGD:1309687