FZD4 - frizzled class receptor 4 Gene

Homo sapiens

Also known as Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S

Gene ID: 8322 | Gene type: protein coding

About FZD4

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,945,679-86,955,395 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues, 15 paralogues and is associated with 5 phenotypes. Broad expression in fat (RPKM 98.6), kidney (RPKM 18.6) and 14 other tissues.

Summary

This gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by Other experimental evidence. [provided by RefSeq, Jul 2008]

FZD4 Products(1)

mRNA	Protein	Name
NM_012193.4	NP_036325.2	frizzled-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	20802536	GOA
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	19388021	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	28733458	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	18234671	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	17955262	GOA
enables cytokine receptor activity	IDA IDA: Inferred from direct assay	17955262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17955262	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	18234671	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22575959	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Norrin signaling pathway	IDA IDA: Inferred from direct assay	15035989	GOA
involved in Wnt signaling pathway, calcium modulating pathway	IDA IDA: Inferred from direct assay	12172548	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14688793	GOA
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	18156211	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14688793	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15035989	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22057916	GOA
involved in retina vasculature morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	12172548	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19643732	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12172548	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD4 Protein Structure

Frizzled

0
100
200
300
400
500
537 a.a.

Protein Preferred Names

Protein Names

frizzled-4

WNT receptor frizzled-4

FZD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FZD4	Q9ULV1	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	FZD4	Q9ULV1	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	FZD4	Q9ULV1	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	FZD4	Q9ULV1	NDP	Homo sapiens	Q00604	Imaging	17955262
Intra	FZD4	Q9ULV1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	FZD4	Q9ULV1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	FZD4	Q9ULV1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	FZD4	Q9ULV1	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	FZD4	Q9ULV1	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	FZD4	Q9ULV1	A2M	Homo sapiens	P01023	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74140	Frizzled-4/CD344 Protein, Human (HEK293, His)	Q9ULV1 (F37-E180)	≥95%
HY-P74141	Frizzled-4/CD344 Protein, Human (HEK293, Fc)	Q9ULV1 (F37-E180)	≥95%

Related Diseases

Diseases

Alias

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Vitreoretinopathy

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Osteoporosis-Pseudoglioma Syndrome

OPPG	Ops
Osteoporosis With Pseudoglioma	Osteogenesis Imperfecta, Ocular Form
Ocular Form Of Osteogenesis Imperfecta	Osteogenesis Imperfecta Ocular Form
Osteoporosis Pseudoglioma Syndrome	Pseudoglioma With Bone Fragility

Leukocoria

Leucocoria

Retinal Telangiectasia

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Retinal Vascular Disease

Retinal Vascular	Retinal Vascular Disorder
Retina Circulation Disorder

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Vitreous Disease

Disorder Of Vitreous Body

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117163	FzM1.8	Agonist	98.37%	Unkown
HY-116553	FzM1	Inhibitor	98.62%	Unkown
HY-RS05180	FZD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FZD4	VGNC	VGNC:72836
Felis catus	FZD4	VGNC	VGNC:102891
Mus musculus	FZD4	MGD	MGI:108520
Canis familiaris	FZD4	VGNC	VGNC:41032
Rattus norvegicus	FZD4	RGD	RGD:71017
Bos taurus	FZD4	VGNC	VGNC:29168
Others	FZD4	NCBI

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