FZD8 - frizzled class receptor 8 Gene

Homo sapiens

Also known as FZ-8; hFZ8

Gene ID: 8325 | Gene type: protein coding

About FZD8

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,638,247-35,642,296 (from NCBI)

This gene has 1 transcript (splice variant), 221 orthologues and 15 paralogues.

Summary

This intronless gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human Cancer cell lines, indicating that it may play a role in several types of Cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

FZD8 Products(1)

mRNA	Protein	Name
NM_031866.3	NP_114072.1	frizzled-8 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	18256285	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	28733458	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22682250	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22575959	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28733458	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22138402	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD8 Protein Structure

Frizzled

0
200
400
600
694 a.a.

Protein Preferred Names

Protein Names

frizzled-8

frizzled 8, seven transmembrane spanning receptor

Recombinant FZD8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70915	Frizzled-8 Protein, Human (HEK293, His)	Q9H461 (A28-P172)	≥95%
HY-P72372	Frizzled-8 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9H461 (A28-P172)	≥95%

Related Diseases

Diseases

Alias

Cystitis

Infective Cystitis	Urocystitis
Pyocystitis

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99667	Ipafricept	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05184	FZD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FZD8	RGD	RGD:1560525
Bos taurus	FZD8	VGNC	VGNC:57008
Felis catus	FZD8	VGNC	VGNC:82431
Mus musculus	FZD8	MGD	MGI:108460
Macaca mulatta	FZD8	VGNC	VGNC:72838
Canis familiaris	FZD8	VGNC	VGNC:110465
Others	FZD8	NCBI

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