2. Gene
  3. SF3B5 - splicing factor 3b subunit 5 Gene

SF3B5 - splicing factor 3b subunit 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Ysf3; SF3b10

Gene ID: 83443 | Gene type: protein coding

About SF3B5

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:144,094,884-144,095,573 (from NCBI)

This gene has 1 transcript (splice variant) and 208 orthologues.

Summary

Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

SF3B5 Products(1)

mRNA Protein Name
NM_031287.3 NP_112577.1 splicing factor 3B subunit 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
27720643 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17332742 GOA
enables splicing factor binding IDA
IDA: Inferred from direct assay
27720643 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
27720643 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of U2-type spliceosomal complex IPI
IPI: Inferred from physical interaction
27720643 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27720643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B5 Protein Structure

SF3b10

SF3b10: Splicing factor 3B subunit 10 (SF3b10) (3 - 80)

  • 0
  • 86 a.a.
Protein Preferred Names Protein Names

splicing factor 3B subunit 5

pre-mRNA-splicing factor SF3b 10 kDa subunit

SF3B5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SF3B5 Q9BWJ5 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12764 SF3B5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SF3B5 MGD MGI:1913375
Canis familiaris SF3B5 VGNC VGNC:46073
Bos taurus SF3B5 VGNC VGNC:34512
Felis catus SF3B5 VGNC VGNC:65059
Rattus norvegicus SF3B5 RGD RGD:1586993