FRMD8 - FERM domain containing 8 Gene

Homo sapiens

Also known as iTAP; FKSG44

Gene ID: 83786 | Gene type: protein coding

About FRMD8

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,368,026-65,426,526 (from NCBI)

This gene has 9 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 9.9), skin (RPKM 9.0) and 25 other tissues.

Summary

Involved in positive regulation of tumor necrosis factor production. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FRMD8 Products(3)

mRNA	Protein	Name
NM_001300832.3	NP_001287761.1	FERM domain-containing protein 8 isoform 2
NM_001300833.3	NP_001287762.1	FERM domain-containing protein 8 isoform 3
NM_031904.5	NP_114110.1	FERM domain-containing protein 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	29897333	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	29897336	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	29897333	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	29897333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRMD8 Protein Structure

FERM_M

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

FERM domain-containing protein 8

band4.1 inhibitor LRP interactor

FRMD8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FRMD8	Q9BZ67	KCNH2	Homo sapiens	Q12809-2	Y2H Array	32296183
Intra	FRMD8	Q9BZ67	KCNH2	Homo sapiens	Q12809-2	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	FRMD8	Q9BZ67	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	FRMD8	Q9BZ67	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	FRMD8	Q9BZ67	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	32296183
Intra	FRMD8	Q9BZ67	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	25416956
Intra	FRMD8	Q9BZ67	GRAMD2B	Homo sapiens	Q96HH9	Validated Y2H	25416956
Intra	FRMD8	Q9BZ67	GRAMD2B	Homo sapiens	Q96HH9	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	32296183
Intra	FRMD8	Q9BZ67	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Array	32296183
Intra	FRMD8	Q9BZ67	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	FRMD8	Q9BZ67	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956
Intra	FRMD8	Q9BZ67	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	FRMD8	Q9BZ67	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	FRMD8	Q9BZ67	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tylosis With Esophageal Cancer

Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome	TOC
Keratosis Palmaris Et Plantaris With Esophageal Cancer	Bennion-Patterson Syndrome
Howell-Evans Syndrome	Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome
Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome	Tylosis-Oesophageal Carcinoma Syndrome
Palmoplantar Keratoderma With Esophageal Cancer	Howel-Evans Syndrome
Keratosis Palmoplantaris With Esophageal Cancer	Tylosis - Oesophageal Carcinoma
Howel-Evans' Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05106	FRMD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FRMD8	RGD	RGD:1310323
Mus musculus	FRMD8	MGD	MGI:1914707
Canis familiaris	FRMD8	VGNC	VGNC:51873
Felis catus	FRMD8	VGNC	VGNC:102893
Bos taurus	FRMD8	VGNC	VGNC:56264
Macaca mulatta	FRMD8	VGNC	VGNC:101087

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