1. Gene
  2. BEX2 - brain expressed X-linked 2 Gene

BEX2 - brain expressed X-linked 2 Gene

Homo sapiens

Also known as BEX1; DJ79P11.1

Gene ID: 84707 | Gene type: protein coding

About BEX2

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,309,346-103,310,990 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 3 paralogues. Broad expression in brain (RPKM 60.5), thyroid (RPKM 40.0) and 14 other tissues.

Summary

This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast Cancer cells, this gene product modulates Apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

BEX2 Products(4)

mRNA Protein Name
NM_001168399.2 NP_001161871.1 protein BEX2 isoform 1
NM_001168400.2 NP_001161872.1 protein BEX2 isoform 2
NM_001168401.2 NP_001161873.1 protein BEX2 isoform 3
NM_032621.4 NP_116010.1 protein BEX2 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
19711341 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
19711341 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEX2 Protein Structure

BEX

BEX: Brain expressed X-linked like family (14 - 127)

  • 0
  • 100
  • 128 a.a.
Protein Preferred Names Protein Names

protein BEX2

brain-expressed X-linked protein 2

BEX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra BEX2 Q9BXY8 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra BEX2 Q9BXY8 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra BEX2 Q9BXY8 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
25416956
Intra BEX2 Q9BXY8 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra BEX2 Q9BXY8 MAGEA11 Homo sapiens P43364-2
Validated Y2H
25416956
Intra BEX2 Q9BXY8 BORCS6 Homo sapiens Q96GS4
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 BORCS6 Homo sapiens Q96GS4
Y2H Array
32296183
Intra BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33
Validated Y2H
25416956
Intra BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33
Y2H Array
25416956
Intra BEX2 Q9BXY8 TRIM74 Homo sapiens Q86UV6-2
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 TRIM74 Homo sapiens Q86UV6-2
Y2H Array
32296183
Intra BEX2 Q9BXY8 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra BEX2 Q9BXY8 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT38 Homo sapiens O76015
Validated Y2H
25416956
Intra BEX2 Q9BXY8 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra BEX2 Q9BXY8 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra BEX2 Q9BXY8 KLHL20 Homo sapiens Q9BS75
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KLHL20 Homo sapiens Q9BS75
Y2H Array
32296183
Intra BEX2 Q9BXY8 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra BEX2 Q9BXY8 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra BEX2 Q9BXY8 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra BEX2 Q9BXY8 TRIM69 Homo sapiens Q86WT6-2
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 TRIM69 Homo sapiens Q86WT6-2
Y2H Array
32296183
Intra BEX2 Q9BXY8 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra BEX2 Q9BXY8 AKAP9 Homo sapiens Q6PJH3
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 AKAP9 Homo sapiens Q6PJH3
Y2H Array
32296183
Intra BEX2 Q9BXY8 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra BEX2 Q9BXY8 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra BEX2 Q9BXY8 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2
Validated Y2H
32296183
Intra BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2
Y2H Array
32296183
Intra BEX2 Q9BXY8 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra BEX2 Q9BXY8 ZNF19 Homo sapiens P17023
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 ZNF19 Homo sapiens P17023
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 FST Homo sapiens P19883
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 FST Homo sapiens P19883
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
25416956
Intra BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9
Y2H Array
25416956
Intra BEX2 Q9BXY8 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra BEX2 Q9BXY8 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra BEX2 Q9BXY8 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra BEX2 Q9BXY8 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3
Validated Y2H
32296183
Intra BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3
Y2H Array
32296183
Intra BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448
Y2H Array
32296183
Intra BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448
Validated Y2H
32296183
Intra BEX2 Q9BXY8 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra BEX2 Q9BXY8 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
25416956
Intra BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra BEX2 Q9BXY8 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra BEX2 Q9BXY8 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra BEX2 Q9BXY8 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra BEX2 Q9BXY8 MAGEA2 Homo sapiens P43356
Y2H Array
32296183
Intra BEX2 Q9BXY8 MAGEA2 Homo sapiens P43356
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1
Y2H Array
25416956
Intra BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1
Validated Y2H
25416956
Intra BEX2 Q9BXY8 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 SYCE1 Homo sapiens Q8N0S2
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT6A Homo sapiens P02538
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRT6A Homo sapiens P02538
Y2H Array
32296183
Intra BEX2 Q9BXY8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra BEX2 Q9BXY8 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra BEX2 Q9BXY8 MRPL38 Homo sapiens Q96DV4
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MRPL38 Homo sapiens Q96DV4
Y2H Array
32296183
Intra BEX2 Q9BXY8 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra BEX2 Q9BXY8 PLA2G10 Homo sapiens O15496
Y2H Array
32296183
Intra BEX2 Q9BXY8 PLA2G10 Homo sapiens O15496
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra BEX2 Q9BXY8 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra BEX2 Q9BXY8 EXOC8 Homo sapiens Q8IYI6
Y2H Array
32296183
Intra BEX2 Q9BXY8 EXOC8 Homo sapiens Q8IYI6
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 CCDC197 Homo sapiens Q8NCU1
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 CCDC197 Homo sapiens Q8NCU1
Y2H Array
32296183
Intra BEX2 Q9BXY8 ROPN1L Homo sapiens Q96C74
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 ROPN1L Homo sapiens Q96C74
Y2H Array
32296183
Intra BEX2 Q9BXY8 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra BEX2 Q9BXY8 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra BEX2 Q9BXY8 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra BEX2 Q9BXY8 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra BEX2 Q9BXY8 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BEX2 RGD RGD:1564643