1. Gene
  2. BEX2 - brain expressed X-linked 2 Gene

BEX2 - brain expressed X-linked 2 Gene

Homo sapiens

Also known as BEX1; DJ79P11.1

Gene ID: 84707 | Gene type: protein coding

About BEX2

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,309,346-103,310,990 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 3 paralogues. Broad expression in brain (RPKM 60.5), thyroid (RPKM 40.0) and 14 other tissues.

Summary

This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast Cancer cells, this gene product modulates Apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

BEX2 Products(4)

mRNA Protein Name
NM_001168399.2 NP_001161871.1 protein BEX2 isoform 1
NM_001168400.2 NP_001161872.1 protein BEX2 isoform 2
NM_001168401.2 NP_001161873.1 protein BEX2 isoform 3
NM_032621.4 NP_116010.1 protein BEX2 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
19711341 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
19711341 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEX2 Protein Structure

BEX

BEX: Brain expressed X-linked like family (14 - 127)

  • 0
  • 100
  • 128 a.a.
Protein Preferred Names Protein Names

protein BEX2

brain-expressed X-linked protein 2

BEX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BEX2 Q9BXY8 KRT40 Homo sapiens Q6A162 25416956
Intra
BEX2 Q9BXY8 KRT40 Homo sapiens Q6A162 25416956
Intra
BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410 32296183
Intra
BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410 25416956
Intra
BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410 32296183
Intra
BEX2 Q9BXY8 NECAB2 Homo sapiens Q7Z6G3-2 25416956
Intra
BEX2 Q9BXY8 NECAB2 Homo sapiens Q7Z6G3-2 25416956
Intra
BEX2 Q9BXY8 KRTAP12-2 Homo sapiens P59991 32296183
Intra
BEX2 Q9BXY8 KRTAP12-2 Homo sapiens P59991 32296183
Intra
BEX2 Q9BXY8 MAGEA11 Homo sapiens P43364-2 25416956
Intra
BEX2 Q9BXY8 BORCS6 Homo sapiens Q96GS4 32296183
Intra
BEX2 Q9BXY8 BORCS6 Homo sapiens Q96GS4 32296183
Intra
BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33 25416956
Intra
BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33 25416956
Intra
BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33 25416956
Intra
BEX2 Q9BXY8 TRIM74 Homo sapiens Q86UV6-2 32296183
Intra
BEX2 Q9BXY8 TRIM74 Homo sapiens Q86UV6-2 32296183
Intra
BEX2 Q9BXY8 NFKBID Homo sapiens Q8NI38 32296183
Intra
BEX2 Q9BXY8 NFKBID Homo sapiens Q8NI38 32296183
Intra
BEX2 Q9BXY8 KRT34 Homo sapiens O76011 32296183
Intra
BEX2 Q9BXY8 KRT34 Homo sapiens O76011 32296183
Intra
BEX2 Q9BXY8 KRT38 Homo sapiens O76015 25416956
Intra
BEX2 Q9BXY8 KRT38 Homo sapiens O76015 25416956
Intra
BEX2 Q9BXY8 KRT38 Homo sapiens O76015 25416956
Intra
BEX2 Q9BXY8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
BEX2 Q9BXY8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
BEX2 Q9BXY8 KLHL20 Homo sapiens Q9BS75 32296183
Intra
BEX2 Q9BXY8 KLHL20 Homo sapiens Q9BS75 32296183
Intra
BEX2 Q9BXY8 CCDC57 Homo sapiens Q2TAC2-2 32296183
Intra
BEX2 Q9BXY8 CCDC57 Homo sapiens Q2TAC2-2 32296183
Intra
BEX2 Q9BXY8 GPRASP3 Homo sapiens Q6PI77 32296183
Intra
BEX2 Q9BXY8 GPRASP3 Homo sapiens Q6PI77 32296183
Intra
BEX2 Q9BXY8 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
BEX2 Q9BXY8 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
BEX2 Q9BXY8 TRIM69 Homo sapiens Q86WT6-2 32296183
Intra
BEX2 Q9BXY8 TRIM69 Homo sapiens Q86WT6-2 32296183
Intra
BEX2 Q9BXY8 MSS51 Homo sapiens Q4VC12 32296183
Intra
BEX2 Q9BXY8 MSS51 Homo sapiens Q4VC12 32296183
Intra
BEX2 Q9BXY8 AKAP9 Homo sapiens Q6PJH3 32296183
Intra
BEX2 Q9BXY8 AKAP9 Homo sapiens Q6PJH3 32296183
Intra
BEX2 Q9BXY8 CDR2 Homo sapiens Q01850 32296183
Intra
BEX2 Q9BXY8 CDR2 Homo sapiens Q01850 32296183
Intra
BEX2 Q9BXY8 CTAG1A Homo sapiens P78358 32296183
Intra
BEX2 Q9BXY8 CTAG1A Homo sapiens P78358 32296183
Intra
BEX2 Q9BXY8 LCN2 Homo sapiens P80188 32296183
Intra
BEX2 Q9BXY8 LCN2 Homo sapiens P80188 32296183
Intra
BEX2 Q9BXY8 KRT39 Homo sapiens Q6A163 32296183
Intra
BEX2 Q9BXY8 KRT39 Homo sapiens Q6A163 32296183
Intra
BEX2 Q9BXY8 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
BEX2 Q9BXY8 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2 32296183
Intra
BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2 32296183
Intra
BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2 32296183
Intra
BEX2 Q9BXY8 SPRY3 Homo sapiens O43610 32296183
Intra
BEX2 Q9BXY8 SPRY3 Homo sapiens O43610 32296183
Intra
BEX2 Q9BXY8 ZNF19 Homo sapiens P17023 32296183
Intra
BEX2 Q9BXY8 ZNF19 Homo sapiens P17023 32296183
Intra
BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
BEX2 Q9BXY8 FST Homo sapiens P19883 32296183
Intra
BEX2 Q9BXY8 FST Homo sapiens P19883 32296183
Intra
BEX2 Q9BXY8 KRTAP21-2 Homo sapiens Q3LI59 32296183
Intra
BEX2 Q9BXY8 KRTAP21-2 Homo sapiens Q3LI59 32296183
Intra
BEX2 Q9BXY8 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
BEX2 Q9BXY8 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064 32296183
Intra
BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064 25416956
Intra
BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064 32296183
Intra
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 25416956
Intra
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 25416956
Intra
BEX2 Q9BXY8 MIPOL1 Homo sapiens Q8TD10 25416956
Intra
BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5 32296183
Intra
BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5 32296183
Intra
BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5 32296183
Intra
BEX2 Q9BXY8 KRT75 Homo sapiens O95678 32296183
Intra
BEX2 Q9BXY8 KRT75 Homo sapiens O95678 32296183
Intra
BEX2 Q9BXY8 PNMA1 Homo sapiens Q8ND90 25416956
Intra
BEX2 Q9BXY8 KRT27 Homo sapiens Q7Z3Y8 32296183
Intra
BEX2 Q9BXY8 KRT27 Homo sapiens Q7Z3Y8 32296183
Intra
BEX2 Q9BXY8 CCDC88B Homo sapiens A6NC98 32296183
Intra
BEX2 Q9BXY8 CCDC88B Homo sapiens A6NC98 32296183
Intra
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 25416956
Intra
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 32296183
Intra
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 25416956
Intra
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 32296183
Intra
BEX2 Q9BXY8 TRAF1 Homo sapiens Q13077 25416956
Intra
BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3 32296183
Intra
BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3 32296183
Intra
BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3 32296183
Intra
BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448 32296183
Intra
BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448 32296183
Intra
BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448 32296183
Intra
BEX2 Q9BXY8 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
BEX2 Q9BXY8 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
BEX2 Q9BXY8 PRDM14 Homo sapiens Q9GZV8 25416956
Intra
BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371 25416956
Intra
BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371 25416956
Intra
BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371 25416956
Intra
BEX2 Q9BXY8 SPRED1 Homo sapiens Q7Z699 32296183
Intra
BEX2 Q9BXY8 SPRED1 Homo sapiens Q7Z699 32296183
Intra
BEX2 Q9BXY8 TRIM42 Homo sapiens Q8IWZ5 25416956
Intra
BEX2 Q9BXY8 TRIM42 Homo sapiens Q8IWZ5 25416956
Intra
BEX2 Q9BXY8 OIP5 Homo sapiens O43482 32296183
Intra
BEX2 Q9BXY8 OIP5 Homo sapiens O43482 32296183
Intra
BEX2 Q9BXY8 MAGEA2 Homo sapiens P43356 32296183
Intra
BEX2 Q9BXY8 MAGEA2 Homo sapiens P43356 32296183
Intra
BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1 25416956
Intra
BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1 25416956
Intra
BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1 25416956
Intra
BEX2 Q9BXY8 SYCE1 Homo sapiens Q8N0S2 32296183
Intra
BEX2 Q9BXY8 SYCE1 Homo sapiens Q8N0S2 32296183
Intra
BEX2 Q9BXY8 KRT6A Homo sapiens P02538 32296183
Intra
BEX2 Q9BXY8 KRT6A Homo sapiens P02538 32296183
Intra
BEX2 Q9BXY8 HSF2BP Homo sapiens O75031 32296183
Intra
BEX2 Q9BXY8 HSF2BP Homo sapiens O75031 32296183
Intra
BEX2 Q9BXY8 TRIM27 Homo sapiens P14373 25416956
Intra
BEX2 Q9BXY8 MRPL38 Homo sapiens Q96DV4 32296183
Intra
BEX2 Q9BXY8 MRPL38 Homo sapiens Q96DV4 32296183
Intra
BEX2 Q9BXY8 MDFI Homo sapiens Q99750 32296183
Intra
BEX2 Q9BXY8 MDFI Homo sapiens Q99750 32296183
Intra
BEX2 Q9BXY8 PLA2G10 Homo sapiens O15496 32296183
Intra
BEX2 Q9BXY8 PLA2G10 Homo sapiens O15496 32296183
Intra
BEX2 Q9BXY8 HSPB2 Homo sapiens Q16082 32296183
Intra
BEX2 Q9BXY8 HSPB2 Homo sapiens Q16082 32296183
Intra
BEX2 Q9BXY8 KRT15 Homo sapiens P19012 25416956
Intra
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 25416956
Intra
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 25416956
Intra
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 25416956
Intra
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
BEX2 Q9BXY8 USHBP1 Homo sapiens Q8N6Y0 32296183
Intra
BEX2 Q9BXY8 USHBP1 Homo sapiens Q8N6Y0 32296183
Intra
BEX2 Q9BXY8 LDOC1 Homo sapiens O95751 32296183
Intra
BEX2 Q9BXY8 LDOC1 Homo sapiens O95751 32296183
Intra
BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
BEX2 Q9BXY8 EXOC8 Homo sapiens Q8IYI6 32296183
Intra
BEX2 Q9BXY8 EXOC8 Homo sapiens Q8IYI6 32296183
Intra
BEX2 Q9BXY8 TRIP6 Homo sapiens Q15654 32296183
Intra
BEX2 Q9BXY8 TRIP6 Homo sapiens Q15654 32296183
Intra
BEX2 Q9BXY8 KRT19 Homo sapiens P08727 32296183
Intra
BEX2 Q9BXY8 KRT19 Homo sapiens P08727 32296183
Intra
BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9 32296183
Intra
BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9 32296183
Intra
BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9 32296183
Intra
BEX2 Q9BXY8 CCDC197 Homo sapiens Q8NCU1 32296183
Intra
BEX2 Q9BXY8 CCDC197 Homo sapiens Q8NCU1 32296183
Intra
BEX2 Q9BXY8 ROPN1L Homo sapiens Q96C74 32296183
Intra
BEX2 Q9BXY8 ROPN1L Homo sapiens Q96C74 32296183
Intra
BEX2 Q9BXY8 KRT31 Homo sapiens Q15323 25416956
Intra
BEX2 Q9BXY8 KRT31 Homo sapiens Q15323 32296183
Intra
BEX2 Q9BXY8 KRT31 Homo sapiens Q15323 32296183
Intra
BEX2 Q9BXY8 PLEKHG4 Homo sapiens Q58EX7 32296183
Intra
BEX2 Q9BXY8 PLEKHG4 Homo sapiens Q58EX7 32296183
Intra
BEX2 Q9BXY8 MORN3 Homo sapiens Q6PF18 32296183
Intra
BEX2 Q9BXY8 MORN3 Homo sapiens Q6PF18 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BEX2 RGD RGD:1564643