STARD3NL - STARD3 N-terminal like Gene

Homo sapiens

Also known as MENTHO

Gene ID: 83930 | Gene type: protein coding

About STARD3NL

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,178,245-38,230,669 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 5 paralogues. Ubiquitous expression in prostate (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues.

Summary

This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds Cholesterol molecules and may play a role in endosomal Cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]

STARD3NL Products(8)

mRNA	Protein	Name
NM_001363339.2	NP_001350268.1	STARD3 N-terminal-like protein isoform 1
NM_001363340.2	NP_001350269.1	STARD3 N-terminal-like protein isoform 1
NM_001363343.2	NP_001350272.1	STARD3 N-terminal-like protein isoform 2
NM_001363344.2	NP_001350273.1	STARD3 N-terminal-like protein isoform 2
NM_001363345.2	NP_001350274.1	STARD3 N-terminal-like protein isoform 2
NM_001363346.2	NP_001350275.1	STARD3 N-terminal-like protein isoform 2
NM_001363347.2	NP_001350276.1	STARD3 N-terminal-like protein isoform 2
NM_032016.4	NP_114405.1	STARD3 N-terminal-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol binding	IDA IDA: Inferred from direct assay	15718238	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15718238	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15718238	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in vesicle tethering to endoplasmic reticulum	IDA IDA: Inferred from direct assay	24105263	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24105263	GOA
located in endoplasmic reticulum-endosome membrane contact site	IDA IDA: Inferred from direct assay	24105263	GOA
located in endosome	IDA IDA: Inferred from direct assay	29858488	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	24105263	GOA
located in organelle membrane contact site	IDA IDA: Inferred from direct assay	24105263	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STARD3NL Protein Structure

MENTAL

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

STARD3 N-terminal-like protein

MLN64 N-terminal domain homolog

STARD3NL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STARD3NL	O95772	HCST	Homo sapiens	Q9UBK5	Y2H Prey Pooling	32296183
Intra	STARD3NL	O95772	HCST	Homo sapiens	Q9UBK5	Validated Y2H	32296183
Intra	STARD3NL	O95772	HCST	Homo sapiens	Q9UBK5	Y2H Array	32296183
Intra	STARD3NL	O95772	MOSPD2	Homo sapiens	Q8NHP6	Anti Tag CoIP	29858488
Intra	STARD3NL	O95772	MOSPD2	Homo sapiens	Q8NHP6	Pull Down	29858488
Intra	STARD3NL	O95772	MOSPD2	Homo sapiens	Q8NHP6	Anti Tag CoIP	33961781
Intra	STARD3NL	O95772	MOSPD2	Homo sapiens	Q8NHP6	Confocal	29858488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 51

IMD51	Candf5
Candidiasis, Familial, 5	Candidiasis, Familial, 5, Formerly
Candf5, Formerly	Familial Candidiasis 5
Candidiasis Familial 5 Autosomal Recessive	Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive
Chronic Mucocutaneous Candidiasis 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13879	STARD3NL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STARD3NL	VGNC	VGNC:35364
Canis familiaris	STARD3NL	VGNC	VGNC:46883
Macaca mulatta	STARD3NL	VGNC	VGNC:84755
Felis catus	STARD3NL	VGNC	VGNC:65754
Rattus norvegicus	STARD3NL	RGD	RGD:1308633
Mus musculus	STARD3NL	MGD	MGI:1923455

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