PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Gene

Homo sapiens

Gene ID: 8394 | Gene type: protein coding

About PIP5K1A

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,195,419-151,249,531 (from NCBI)

This gene has 17 transcripts (splice variants), 239 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 22.2), placenta (RPKM 13.0) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]

PIP5K1A Products(5)

mRNA	Protein	Name
NM_001135636.2	NP_001129108.1	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3
NM_001135637.2	NP_001129109.1	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4
NM_001135638.2	NP_001129110.1	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1
NM_001330689.2	NP_001317618.1	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 5
NM_003557.3	NP_003548.1	phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA IDA: Inferred from direct assay	15157668	GOA
enables kinase binding	IDA IDA: Inferred from direct assay	15157668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15157668	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20660631	GOA
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20660631	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	20660631	GOA
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	20660631	GOA
involved in phospholipid biosynthetic process	IDA IDA: Inferred from direct assay	15157668	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20660631	GOA
involved in ruffle assembly	IMP IMP: Inferred from mutant phenotype	20660631	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lamellipodium	IDA IDA: Inferred from direct assay	15157668	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	18305108	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	18288197	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15157668	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20660631	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	20660631	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP5K1A Protein Structure

PIP5K

0
100
200
300
400
500
562 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha

PIP5K1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PIP5K1A	Q99755	KRAS	Homo sapiens	P01116	Pull Down	30194290
Intra	PIP5K1A	Q99755	KRAS	Homo sapiens	P01116	Anti Bait CoIP	30194290
Intra	PIP5K1A	Q99755	KRAS	Homo sapiens	P01116	Anti Tag CoIP	30194290

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10566	PIP5K1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PIP5K1A	VGNC	VGNC:55656
Mus musculus	PIP5K1A	MGD	MGI:107929
Macaca mulatta	PIP5K1A	VGNC	VGNC:100037
Felis catus	PIP5K1A	VGNC	VGNC:80303
Rattus norvegicus	PIP5K1A	RGD	RGD:1306127

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