TSSK6 - testis specific serine kinase 6 Gene

Homo sapiens

Also known as CT72; SSTK; TSSK4; FKSG82

Gene ID: 83983 | Gene type: protein coding

About TSSK6

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,514,219-19,515,548 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 17 paralogues.

Summary

This intronless gene encodes a member of the CaMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

TSSK6 Products(1)

mRNA	Protein	Name
NM_032037.4	NP_114426.1	testis-specific serine/threonine-protein kinase 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	15870294	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	15870294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15870294	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15870294	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15870294	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSSK6 Protein Structure

Pkinase

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

testis-specific serine/threonine-protein kinase 6

TSK-6

TSSK6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSSK6	Q9BXA6	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	TSSK6	Q9BXA6	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	TSSK6	Q9BXA6	HSP90AA1	Homo sapiens	P07900	Lumier	25036637
Intra	TSSK6	Q9BXA6	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	TSSK6	Q9BXA6	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	TSSK6	Q9BXA6	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	15870294
Intra	TSSK6	Q9BXA6	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	TSSK6	Q9BXA6	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	TSSK6	Q9BXA6	HSP90AB1	Homo sapiens	P08238	Lumier	22939624

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oligospermia

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15189	TSSK6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSSK6	MGD	MGI:2148775
Rattus norvegicus	TSSK6	RGD	RGD:1559764
Canis familiaris	TSSK6	VGNC	VGNC:55009
Bos taurus	TSSK6	VGNC	VGNC:50152
Felis catus	TSSK6	VGNC	VGNC:66646

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