CTTNBP2 - cortactin binding protein 2 Gene

Homo sapiens

Also known as Orf4; C7orf8; CORTBP2

Gene ID: 83992 | Gene type: protein coding

About CTTNBP2

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:117,710,651-117,873,441 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues and 4 paralogues. Broad expression in brain (RPKM 5.1), esophagus (RPKM 3.1) and 19 other tissues.

Summary

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

CTTNBP2 Products(4)

mRNA	Protein	Name
NM_001363349.1	NP_001350278.1	cortactin-binding protein 2 isoform 2
NM_001363350.1	NP_001350279.1	cortactin-binding protein 2 isoform 3
NM_001363351.1	NP_001350280.1	cortactin-binding protein 2 isoform 3
NM_033427.3	NP_219499.1	cortactin-binding protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTTNBP2 Protein Structure

CortBP2

Ank_2

Ank

0
300
600
900
1200
1500
1663 a.a.

Protein Preferred Names

Protein Names

cortactin-binding protein 2

CORTBP2, C7orf8

CTTNBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CTTNBP2	Q8WZ74	BMAL2	Homo sapiens	Q8WYA1-3	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	BMAL2	Homo sapiens	Q8WYA1-3	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
Intra	CTTNBP2	Q8WZ74	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	PKNOX2	Homo sapiens	Q96KN3	Validated Y2H	32296183
Intra	CTTNBP2	Q8WZ74	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	KRT14	Homo sapiens	P02533	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	CTTNBP2	Q8WZ74	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	CTTNBP2	Q8WZ74	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Noonan Syndrome 12

NS12

Brachial Plexus Neuritis

Brachial Neuritis

Parsonage-Aldren-Turner Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03351	CTTNBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03352	CTTNBP2NL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTTNBP2	VGNC	VGNC:71409
Canis familiaris	CTTNBP2	VGNC	VGNC:39719
Bos taurus	CTTNBP2	VGNC	VGNC:27822
Rattus norvegicus	CTTNBP2	RGD	RGD:628691
Mus musculus	CTTNBP2	MGD	MGI:1353467
Felis catus	CTTNBP2	VGNC	VGNC:78436

Name
Email *

	Sorry, but the email address you supplied was invalid.