KATNAL1 - katanin catalytic subunit A1 like 1 Gene

Homo sapiens

Gene ID: 84056 | Gene type: protein coding

About KATNAL1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,202,630-30,307,551 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 9 paralogues. Broad expression in testis (RPKM 4.9), brain (RPKM 4.4) and 24 other tissues.

Summary

Enables identical protein binding activity and microtubule-severing ATPase activity. Involved in microtubule severing. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

KATNAL1 Products(2)

mRNA	Protein	Name
NM_001014380.3	NP_001014402.1	katanin p60 ATPase-containing subunit A-like 1
NM_032116.5	NP_115492.1	katanin p60 ATPase-containing subunit A-like 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables microtubule severing ATPase activity	IDA IDA: Inferred from direct assay	26929214	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in microtubule severing	IDA IDA: Inferred from direct assay	26929214	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26929214	GOA
part of katanin complex	IPI IPI: Inferred from physical interaction	26929214	GOA
located in microtubule	IDA IDA: Inferred from direct assay	26929214	GOA
located in spindle	IDA IDA: Inferred from direct assay	26929214	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	26929214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KATNAL1 Protein Structure

AAA

Vps4_C

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

katanin p60 ATPase-containing subunit A-like 1

katanin catalytic subunit A like 1

KATNAL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	CEP57L1	Homo sapiens	Q8IYX8	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	KATNB1	Homo sapiens	Q9BVA0	TAP	26929214
Intra	KATNAL1	Q9BW62	KATNB1	Homo sapiens	Q9BVA0	Anti Tag CoIP	26929214
Intra	KATNAL1	Q9BW62	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	ZNF69	Homo sapiens	Q9UC07-2	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	ZNF69	Homo sapiens	Q9UC07-2	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	ZNF69	Homo sapiens	Q9UC07-2	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	PITPNC1	Homo sapiens	Q9UKF7-2	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	PGAM2	Homo sapiens	P15259	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	PGAM2	Homo sapiens	P15259	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	ASCC2	Homo sapiens	Q9H1I8	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	ASCC2	Homo sapiens	Q9H1I8	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	ASCC2	Homo sapiens	Q9H1I8	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	COX17	Homo sapiens	Q14061	Validated Y2H	25416956
Intra	KATNAL1	Q9BW62	COX17	Homo sapiens	Q14061	Y2H Array	25416956
Intra	KATNAL1	Q9BW62	COX17	Homo sapiens	Q14061	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	TAP	26929214
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Anti Tag CoIP	26929214
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	KATNAL1	Q9BW62	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	KATNAL1	Q9BW62	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	KATNAL1	Q9BW62	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	KATNAL1	Q9BW62	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	KLC4	Homo sapiens	Q9NSK0	Validated Y2H	32296183
Intra	KATNAL1	Q9BW62	KLC4	Homo sapiens	Q9NSK0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Joubert Syndrome 26

JBTS26

Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07085	KATNAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KATNAL1	VGNC	VGNC:42217
Macaca mulatta	KATNAL1	VGNC	VGNC:73917
Rattus norvegicus	KATNAL1	RGD	RGD:1359252
Bos taurus	KATNAL1	VGNC	VGNC:30406
Mus musculus	KATNAL1	MGD	MGI:2387638
Felis catus	KATNAL1	VGNC	VGNC:63028

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