KLC4 - kinesin light chain 4 Gene

Homo sapiens

Also known as KNSL8; bA387M24.3

Gene ID: 89953 | Gene type: protein coding

About KLC4

This gene has 19 transcripts (splice variants), 381 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues.

Summary

Predicted to be located in cytoplasm and microtubule. Predicted to be part of Kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]

KLC4 Products(6)

mRNA	Protein	Name
NM_001289034.2	NP_001275963.1	kinesin light chain 4 isoform a
NM_001289035.2	NP_001275964.1	kinesin light chain 4 isoform d
NM_138343.4	NP_612352.1	kinesin light chain 4 isoform c
NM_201521.3	NP_958929.1	kinesin light chain 4 isoform a
NM_201522.3	NP_958930.1	kinesin light chain 4 isoform a
NM_201523.3	NP_958931.1	kinesin light chain 4 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLC4 Protein Structure

Rab5-bind

TPR_2

TPR_12

TPR_10

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

kinesin light chain 4

kinesin-like protein 8

KLC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	KLC4	Q9NSK0	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SLC16A9	Homo sapiens	Q7RTY1	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	ZNF343	Homo sapiens	Q6P1L6	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	ZNF343	Homo sapiens	Q6P1L6	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KLC4	Q9NSK0	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	KLC4	Q9NSK0	TADA2A	Homo sapiens	O75478	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Array	32296183
Intra	KLC4	Q9NSK0	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	KLC4	Q9NSK0	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Ehlers-Danlos Syndrome, Vascular Type

Eds Iv	Eds4
Vascular Ehlers-Danlos Syndrome	Veds
Sack-Barabas Syndrome	EDSVASC
Ehlers-Danlos Syndrome, Type Iv, Autosomal Dominant	Vascular Type Ehlers-Danlos Syndrome
Arterial-Ecchymotic Eds	Ehlers-Danlos Syndrome Type 4
Vascular Eds	Ehlers-Danlos Syndrome, Type 4
Ehlers-Danlos Syndrome, Type Iv	Ehlers-Danlos Syndrome, Arterial Type
Ehlers-Danlos Syndrome, Ecchymotic Type	Ehlers-Danlos Syndrome, Sack-Barabas Type
Autosomal Dominant Type Iv Ehlers-Danlos Syndrome	Eds Type Iv
Eds Type 4	Ehlers Danlos Syndrome, Sack-Barabas Type
Ehlers Danlos Syndrome, Arterial Type	Ehlers Danlos Syndrome, Ecchymotic Type
Ehlers-Danlos Syndrome Type Iv	Ehlers-Danlos Syndrome 4
Ehlers-Danlos Syndrome Arterial Type	Ehlers-Danlos Syndrome Ecchymotic Type
Ehlers-Danlos Syndrome, Type 4 Variant	Ehlers-Danlos, Vascular Type Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07329	KLC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLC4	VGNC	VGNC:73880
Felis catus	KLC4	VGNC	VGNC:63129
Canis familiaris	KLC4	VGNC	VGNC:42429
Rattus norvegicus	KLC4	RGD	RGD:1306555
Mus musculus	KLC4	MGD	MGI:1922014
Bos taurus	KLC4	VGNC	VGNC:30625

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