TAGLN2 - transgelin 2 Gene

Homo sapiens

Also known as HA1756

Gene ID: 8407 | Gene type: protein coding

About TAGLN2

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,918,111-159,925,507 (from NCBI)

This gene has 5 transcripts (splice variants), 150 orthologues and 5 paralogues. Ubiquitous expression in lung (RPKM 268.8), stomach (RPKM 231.0) and 25 other tissues.

Summary

The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

TAGLN2 Products(3)

mRNA	Protein	Name
NM_001277223.2	NP_001264152.1	transgelin-2 isoform b
NM_001277224.2	NP_001264153.1	transgelin-2 isoform a
NM_003564.3	NP_003555.1	transgelin-2 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21577206	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	21492153	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAGLN2 Protein Structure

Calponin

0
100
199 a.a.

Protein Preferred Names

Protein Names

transgelin-2

SM22-alpha homolog

TAGLN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAGLN2	P37802	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	TAGLN2	P37802	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	TAGLN2	P37802	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	TAGLN2	P37802	TAGLN3	Homo sapiens	Q9UI15	Anti Tag CoIP	33961781
Intra	TAGLN2	P37802	TAGLN3	Homo sapiens	Q9UI15	Anti Tag CoIP	28514442
Intra	TAGLN2	P37802	ACTB	Homo sapiens	P60709	Anti Tag CoIP	21577206
Intra	TAGLN2	P37802	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	TAGLN2	P37802	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	TAGLN2	P37802	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	TAGLN2	P37802	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	TAGLN2	P37802	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	TAGLN2	P37802	HTT	Homo sapiens	P42858	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa

Maxillary Sinus Cancer

Malignant Neoplasm Of Antrum	Malignant Tumor Of The Maxillary Sinus
Maxillary Sinus Carcinoma	Cancer Of Maxillary Sinus
Maxillary Sinus Neoplasms

Maxillary Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Maxillofacial Sinus

Esophagus Adenocarcinoma

Esophageal Adenocarcinoma	Oesophageal Adenocarcinoma
Adenocarcinoma Of Esophagus	Adenocarcinoma Of The Esophagus

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14187	TAGLN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TAGLN2	VGNC	VGNC:65944
Canis familiaris	TAGLN2	VGNC	VGNC:47094
Mus musculus	TAGLN2	MGD	MGI:1312985
Bos taurus	TAGLN2	VGNC	VGNC:35586
Rattus norvegicus	TAGLN2	RGD	RGD:1310840
Others	TAGLN2	NCBI

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