2. Gene
  3. ZRANB3 - zinc finger RANBP2-type containing 3 Gene

ZRANB3 - zinc finger RANBP2-type containing 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AH2; 4933425L19Rik

Gene ID: 84083 | Gene type: protein coding

About ZRANB3

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:135,196,969-135,531,218 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 30 paralogues. Broad expression in testis (RPKM 1.8), thyroid (RPKM 0.8) and 24 other tissues.

Summary

Enables ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Located in nuclear replication fork and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZRANB3 Products(3)

mRNA Protein Name
NM_001286568.2 NP_001273497.1 DNA annealing helicase and endonuclease ZRANB3 isoform 2
NM_001286569.1 NP_001273498.1 DNA annealing helicase and endonuclease ZRANB3 isoform 3
NM_032143.4 NP_115519.2 DNA annealing helicase and endonuclease ZRANB3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP-dependent DNA/DNA annealing activity IDA
IDA: Inferred from direct assay
21078962 GOA
enables DNA endonuclease activity IDA
IDA: Inferred from direct assay
22759634 GOA
NOT enables DNA helicase activity IDA
IDA: Inferred from direct assay
21078962 GOA
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
22704558 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22704558 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
22704558 GOA
involved in DNA repair IDA
IDA: Inferred from direct assay
22759634 GOA
involved in DNA rewinding IDA
IDA: Inferred from direct assay
21078962 GOA
involved in negative regulation of DNA recombination IDA
IDA: Inferred from direct assay
22704558 GOA
involved in replication fork processing IDA
IDA: Inferred from direct assay
22704558 GOA
involved in replication fork reversal IDA
IDA: Inferred from direct assay
22704558 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
22704558 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear replication fork IDA
IDA: Inferred from direct assay
22704558 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZRANB3 Protein Structure

SNF2_N

SNF2_N: SNF2 family N-terminal domain (51 - 286)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (361 - 435)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (625 - 647)

HNH

HNH: HNH endonuclease (1011 - 1051)

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  • 1000
  • 1079 a.a.
Protein Preferred Names Protein Names

DNA annealing helicase and endonuclease ZRANB3

annealing helicase 2

ZRANB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZRANB3 Q5FWF4 PCNA Homo sapiens P12004
Confocal
22759634
Intra
ZRANB3 Q5FWF4 PCNA Homo sapiens P12004
Anti Tag CoIP
22759634
Intra
ZRANB3 Q5FWF4 PCNA Homo sapiens P12004
Pull Down
22759634
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schimke Immunoosseous Dysplasia

Schimke Immuno-Osseous Dysplasia

SIOD

Immunoosseous Dysplasia, Schimke Type

Schimke Syndrome

Immunoosseous Dysplasia Schimke Type

Spondyloepiphyseal Dysplasia - Nephrotic Syndrome

Spondyloepiphyseal Dysplasia Nephrotic Syndrome

Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Amelogenesis Imperfecta, Type If

Amelogenesis Imperfecta Type 1f

AI1F

Amelogenesis Imperfecta, Hypoplastic Type If

Amelogenesis Imperfecta Type If

Amelogenesis Imperfecta Hypoplastic Type If

Amelogenesis Imperfecta 1f
Chronic Inducible Urticaria
Hypotrichosis 7

Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis

HYPT7

Hypotrichosis, Localized, Autosomal Recessive 2

Lah2

Ah

Total Hypotrichosis, Mari Type

Wh/Ht

Hypotrichosis, Autosomal Recessive

Hypotrichosis, Total, Mari Type

Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis

Total Mari Type Hypotrichosis

Alopecia Universalis Congenita, Mari Type

Mari Type Alopecia Universalis Congenita

Autosomal Recessive Hypotrichosis

Autosomal Recessive Localized Hypotrichosis

Autosomal Recessive Woolly Hair With Or Without Hypotrichosis

Htl

Hypotrichoses

Hypotrichosis

Lah

Alopecia Universalis Congenita Mari Type

Hypotrichosis Autosomal Recessive

Hypotrichosis Localized Autosomal Recessive 2

Total Hypotrichosis Mari Type

Woolly Hair Autosomal Recessive 2

ARWH2

Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis
Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia
Cerebellar Ataxia Type 9

Sca9
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16195 ZRANB3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZRANB3 MGD MGI:1918362
Macaca mulatta ZRANB3 VGNC VGNC:79486
Felis catus ZRANB3 VGNC VGNC:80416
Canis familiaris ZRANB3 VGNC VGNC:48849
Rattus norvegicus ZRANB3 RGD RGD:1564952
Bos taurus ZRANB3 VGNC VGNC:37373