TRAF7 - TNF receptor associated factor 7 Gene

Homo sapiens

Also known as RFWD1; RNF119; CAFDADD

Gene ID: 84231 | Gene type: protein coding

About TRAF7

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,155,782-2,178,129 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues, 14 paralogues and is associated with 100 phenotypes. Ubiquitous expression in duodenum (RPKM 19.0), esophagus (RPKM 17.7) and 25 other tissues.

Summary

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF Receptor Superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

TRAF7 Products(1)

mRNA	Protein	Name
NM_032271.3	NP_115647.2	E3 ubiquitin-protein ligase TRAF7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21518757	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14743216	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	15001576	GOA
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15001576	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	14743216	GOA
involved in positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15001576	GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21518757	GOA
involved in protein K29-linked ubiquitination	IDA IDA: Inferred from direct assay	21518757	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14743216	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	29961569	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14743216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF7 Protein Structure

zf-C3HC4_2

zf-TRAF

WD40

0
200
400
600
670 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRAF7

RING finger and WD repeat-containing protein 1

TRAF7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	TRAF7	Q6Q0C0	Ripk4	Mus musculus	Q9ERK0	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cardiac, Facial, And Digital Anomalies With Developmental Delay

CAFDADD

Traf7-Associated Heart Defect-Digital Anomalies-Facial Dysmorphism-Motor And Speech Delay Syndrome

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Skull Base Meningioma

Meningioma Of The Skull Base

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Adenomatoid Tumor

Adenomatoid Tumour	Benign Localised Epithelial Mesothelioma
Benign Localized Epithelial Mesothelioma

Anterior Cranial Fossa Meningioma

Meningioma Of The Anterior Fossa

Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove

Angiomatous Meningioma

Intraneural Perineurioma

Meningothelial Meningioma

Meningotheliomatous Meningioma

Secretory Meningioma

Meningioma

Chordoid Meningioma

Meningioma, Chordoid

Transitional Meningioma

Intraventricular Meningioma

Clear Cell Meningioma

Sphenoorbital Meningioma

Brain Meningioma

Intracranial Meningioma

Cerebral Convexity Meningioma

Cerebral Hemispheric Convexity Meningioma

Childhood Meningioma

Pediatric Meningioma

Rhabdoid Meningioma

Papillary Meningioma

Meningioma, Rhabdoid

Foramen Magnum Meningioma

Meningioma Of The Foramen Magnum

Cerebral Falx Meningioma

Falcine Meningioma

Falx Cerebri Meningioma

Spinal Meningioma

Spinal Cord Meningioma	Meningioma, Spine
Meningioma	Meningioma, Benign, No Icd-O Subtype

Spinal Canal And Spinal Cord Meningioma

Intracranial Meningioma

Meningioma

Psammomatous Meningioma

Fibrous Meningioma

Fibroblastic Meningioma

Parasagittal Meningioma

Cavernous Sinus Meningioma

Meningioma Of The Cavernous Sinus

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Microcystic Meningioma

Tuberculum Sellae Meningioma

Meningioma Of The Tuberculum Sellae

Sella Turcica Neoplasm

Tumor Of Sella Turcica

Petroclival Meningioma

Benign Meningioma

Meningioma, Benign

Cerebral Meningioma

Meningioma Of Cerebrum

Optic Nerve Sheath Meningioma

Meningioma Of Optic Nerve Sheath

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Spinal Cancer

Spinal Cord Neoplasm	Spinal Cord Neoplasms
Spinal Neoplasms	Intraspinal Tumor
Malignant Tumor Of The Spinal Cord	Spinal Cord Cancer
Spinal Neoplasm	Tumor Of The Spinal Cord
Tumors Spinal Cord	Intraspinal Neoplasm
Spinal Cord--Cancer

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14976	TRAF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRAF7	VGNC	VGNC:66502
Rattus norvegicus	TRAF7	RGD	RGD:1559653
Canis familiaris	TRAF7	VGNC	VGNC:47770
Bos taurus	TRAF7	VGNC	VGNC:36279
Macaca mulatta	TRAF7	VGNC	VGNC:79252
Mus musculus	TRAF7	MGD	MGI:3042141