MED10 - mediator complex subunit 10 Gene

Homo sapiens

Also known as L6; NUT2; TRG20

Gene ID: 84246 | Gene type: protein coding

About MED10

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:6,371,874-6,378,547 (from NCBI)

This gene has 3 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in bone marrow (RPKM 22.5), lymph node (RPKM 18.2) and 25 other tissues.

Summary

MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED10 Products(1)

mRNA	Protein	Name
NM_032286.3	NP_115662.2	mediator of RNA polymerase II transcription subunit 10

MED10 Protein Structure

Med10

0
100
135 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 10

TRG-17

MED10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED10	Q9BTT4	ARHGDIG	Homo sapiens	Q99819	Y2H Array	32296183
Intra	MED10	Q9BTT4	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	MED10	Q9BTT4	TRIM45	Homo sapiens	Q9H8W5-2	Validated Y2H	32296183
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	24882805
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	33961781
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	15175163
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Ion Exchange Chrom	15175163
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	EM	24882805
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	35271311
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	14576168

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Intellectual Developmental Disorder, Autosomal Dominant 48

Mental Retardation, Autosomal Dominant 48	MRD48
Autosomal Dominant Mental Retardation 48	Autosomal Dominant Intellectual Developmental Disorder 48

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08279	MED10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MED10	RGD	RGD:1310128
Mus musculus	MED10	MGD	MGI:106331
Macaca mulatta	MED10	VGNC	VGNC:110451
Bos taurus	MED10	VGNC	VGNC:31347
Canis familiaris	MED10	VGNC	VGNC:43118
Others	MED10	NCBI

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