MED7 - mediator complex subunit 7 Gene

Homo sapiens

Also known as ARC34; CRSP9; CRSP33

Gene ID: 9443 | Gene type: protein coding

About MED7

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,137,424-157,142,865 (from NCBI)

This gene has 3 transcripts (splice variants), 150 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.9) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MED7 Products(2)

mRNA	Protein	Name
NM_001100816.1	NP_001094286.1	mediator of RNA polymerase II transcription subunit 7
NM_004270.5	NP_004261.1	mediator of RNA polymerase II transcription subunit 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14576168	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9989412	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9989412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED7 Protein Structure

Med7

0
100
200
233 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 7

CRSP complex subunit 9

MED7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED7	O43513	CAB39	Homo sapiens	Q9Y376	Validated Y2H	32296183
Intra	MED7	O43513	MED10	Homo sapiens	Q9BTT4	TAP	24981860
Intra	MED7	O43513	MED10	Homo sapiens	Q9BTT4	Anti Tag CoIP	33961781
Intra	MED7	O43513	MED10	Homo sapiens	Q9BTT4	Anti Tag CoIP	28514442
Intra	MED7	O43513	MED26	Homo sapiens	O95402	Anti Tag CoIP	33961781
Intra	MED7	O43513	MED26	Homo sapiens	O95402	Anti Tag CoIP	24882805
Intra	MED7	O43513	MED26	Homo sapiens	O95402	Anti Tag CoIP	28514442
Intra	MED7	O43513	MED26	Homo sapiens	O95402	TAP	24981860
Intra	MED7	O43513	MED1	Homo sapiens	Q15648	Anti Tag CoIP	33961781
Intra	MED7	O43513	MED1	Homo sapiens	Q15648	TAP	24981860
Intra	MED7	O43513	MED1	Homo sapiens	Q15648	Anti Tag CoIP	28514442
Intra	MED7	O43513	MED1	Homo sapiens	Q15648	Anti Tag CoIP	24882805
Intra	MED7	O43513	MED21	Homo sapiens	Q13503	TAP	24981860
Intra	MED7	O43513	MED31	Homo sapiens	Q9Y3C7	Anti Tag CoIP	33961781
Intra	MED7	O43513	MED31	Homo sapiens	Q9Y3C7	Anti Tag CoIP	28514442
Intra	MED7	O43513	MED31	Homo sapiens	Q9Y3C7	Y2H Array	20211142
Intra	MED7	O43513	MED31	Homo sapiens	Q9Y3C7	TAP	24981860
Cross	MED7	O43513	env	Human T-cell leukemia virus	P03383	Y2H Pooling	22458338
Cross	MED7	O43513	env	Human T-cell leukemia virus	P03383	MAPPIT	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Luminal Breast Carcinoma A

Breast Tumor Luminal	Luminal A Breast Carcinoma
Luminal Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08305	MED7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MED7	RGD	RGD:6494481
Mus musculus	MED7	MGD	MGI:1913463
Canis familiaris	MED7	VGNC	VGNC:43141
Bos taurus	MED7	VGNC	VGNC:109391
Macaca mulatta	MED7	VGNC	VGNC:74564
Felis catus	MED7	VGNC	VGNC:102252

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