DCUN1D5 - defective in cullin neddylation 1 domain containing 5 Gene

Homo sapiens

Also known as DCNL5; SCCRO5

Gene ID: 84259 | Gene type: protein coding

About DCUN1D5

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:103,050,686-103,092,160 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 3.6), fat (RPKM 1.6) and 25 other tissues.

Summary

Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2022]

DCUN1D5 Products(4)

mRNA	Protein	Name
NM_001318739.2	NP_001305668.1	DCN1-like protein 5 isoform b
NM_001318740.2	NP_001305669.1	DCN1-like protein 5 isoform c
NM_001318741.2	NP_001305670.1	DCN1-like protein 5 isoform c
NM_032299.4	NP_115675.1	DCN1-like protein 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cullin family protein binding	IMP IMP: Inferred from mutant phenotype	23201271	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23201271	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23098533	GOA
involved in positive regulation of protein neddylation	IMP IMP: Inferred from mutant phenotype	23201271	GOA
involved in regulation of cell growth	IMP IMP: Inferred from mutant phenotype	24192928	GOA
involved in regulation of protein neddylation	IMP IMP: Inferred from mutant phenotype	19617556	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18445686	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	23098533	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCUN1D5 Protein Structure

Cullin_binding

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

DCN1-like protein 5

DCN1, defective in cullin neddylation 1, domain containing 5

DCUN1D5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCUN1D5	Q9BTE7	HUS1	Homo sapiens	O60921	Y2H Array	32296183
Intra	DCUN1D5	Q9BTE7	HUS1	Homo sapiens	O60921	Y2H Prey Pooling	32296183
Intra	DCUN1D5	Q9BTE7	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	DCUN1D5	Q9BTE7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	DCUN1D5	Q9BTE7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	DCUN1D5	Q9BTE7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	DCUN1D5	Q9BTE7	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	DCUN1D5	Q9BTE7	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
Intra	DCUN1D5	Q9BTE7	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03600	DCUN1D5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCUN1D5	VGNC	VGNC:102873
Mus musculus	DCUN1D5	MGD	MGI:1924113
Canis familiaris	DCUN1D5	VGNC	VGNC:53330
Rattus norvegicus	DCUN1D5	RGD	RGD:1307008
Bos taurus	DCUN1D5	VGNC	VGNC:27938
Macaca mulatta	DCUN1D5	VGNC	VGNC:71775

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