2. Gene
  3. Il12a - interleukin 12A Gene

Il12a - interleukin 12A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84405 | Gene type: protein coding

About Il12a

Primary_assembly 2: 152,965,769-152,972,734 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 234 orthologues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 41.7), Uterus (RPKM 24.6) and 6 other tissues.

Summary

Predicted to enable interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface; cytoplasm; and extracellular space. Predicted to be part of interleukin-12 complex. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]

Il12a Products(1)

mRNA Protein Name
NM_053390.1 NP_445842.1 interleukin-12 subunit alpha precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in response to granulocyte colony-stimulating factor IEP
IEP: Inferred from expression pattern
12668156 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il12a Protein Structure

IL12

IL12: pfam03039 (16 - 214)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

interleukin-12 subunit alpha

CLMF p35

IL-12 subunit p35

IL-12A

cytotoxic lymphocyte maturation factor 35 kDa subunit

interleukin 12 p35 subunit

Recombinant Il12a Proteins

Cat. No. Product Name Accession Purity
HY-P7370 IL-12 Protein, Rat (CHO) Q9R103 (R23-S215)&E9PU71 (M23-S335) ≥95%
HY-P72598 IL-12 Protein, Rat (HEK293, His) Q9R103 (R23-S215)&Q9R278 (M23-S335) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12a NCBI NCBI:3592
Macaca fascicularis Il12a NCBI NCBI:102115316
Macaca mulatta Il12a NCBI NCBI:703205