ECRG4 - ECRG4 augurin precursor Gene

Homo sapiens

Also known as C2orf40

Gene ID: 84417 | Gene type: protein coding

About ECRG4

Cytogenetic location: 2q12.2 Genomic coordinates (GRCh38): 2:106,063,241-106,078,155 (from NCBI)

This gene has 6 transcripts (splice variants) and 216 orthologues. Broad expression in fat (RPKM 29.6), thyroid (RPKM 20.4) and 17 other tissues.

Summary

Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway; positive regulation of hormone secretion; and vasopressin secretion. Located in apical plasma membrane; dense core granule; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

ECRG4 Products(1)

mRNA	Protein	Name
NM_032411.3	NP_115787.1	augurin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide hormone activity	IGI IGI: Inferred from genetic interaction	20233222	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuropeptide signaling pathway	IGI IGI: Inferred from genetic interaction	20233222	GOA
involved in positive regulation of corticosterone secretion	IGI IGI: Inferred from genetic interaction	20233222	GOA
involved in positive regulation of corticotropin secretion	IGI IGI: Inferred from genetic interaction	20233222	GOA
involved in positive regulation of corticotropin-releasing hormone secretion	IGI IGI: Inferred from genetic interaction	20233222	GOA
involved in vasopressin secretion	IGI IGI: Inferred from genetic interaction	20233222	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21349154	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21349154	GOA
located in dense core granule	IDA IDA: Inferred from direct assay	17284679	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	17284679	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECRG4 Protein Structure

Augurin

0
100
148 a.a.

Protein Preferred Names

Protein Names

augurin

esophageal cancer related gene 4 protein

ECRG4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ECRG4	Q9H1Z8	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ECRG4	Q9H1Z8	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ECRG4	Q9H1Z8	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ECRG4	Q9H1Z8	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	ECRG4	Q9H1Z8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	ECRG4	Q9H1Z8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Castration-Resistant Prostate Carcinoma

Prostatic Neoplasms, Castration-Resistant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04146	ECRG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ECRG4	RGD	RGD:1305645
Canis familiaris	ECRG4	VGNC	VGNC:52481
Bos taurus	ECRG4	VGNC	VGNC:59206
Mus musculus	ECRG4	MGD	MGI:1926146
Macaca mulatta	ECRG4	VGNC	VGNC:82138
Felis catus	ECRG4	VGNC	VGNC:61714

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