RAB11FIP4 - RAB11 family interacting protein 4 Gene

Homo sapiens

Also known as FIP4-Rab11; RAB11-FIP4

Gene ID: 84440 | Gene type: protein coding

About RAB11FIP4

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,391,675-31,538,211 (from NCBI)

This gene has 11 transcripts (splice variants), 283 orthologues and 1 paralogue. Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues.

Summary

The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

RAB11FIP4 Products(5)

mRNA	Protein	Name
NM_001303542.3	NP_001290471.2	rab11 family-interacting protein 4 isoform 2
NM_001346747.2	NP_001333676.1	rab11 family-interacting protein 4 isoform 3
NM_001346748.2	NP_001333677.1	rab11 family-interacting protein 4 isoform 4
NM_001346749.2	NP_001333678.1	rab11 family-interacting protein 4 isoform 5
NM_032932.6	NP_116321.2	rab11 family-interacting protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12470645	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12470645	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	12470645	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16148947	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cleavage furrow	IDA IDA: Inferred from direct assay	15601896	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	20682791	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
located in midbody	IDA IDA: Inferred from direct assay	15601896	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	12470645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB11FIP4 Protein Structure

RBD-FIP

0
100
200
300
400
500
600
637 a.a.

Protein Preferred Names

Protein Names

rab11 family-interacting protein 4

RAB11 family interacting protein 4 (class II)

RAB11FIP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB11FIP4	Q86YS3	MAD2L2	Homo sapiens	Q9UI95	Validated Y2H	32296183
Cross	RAB11FIP4	Q86YS3	Arf6	Mus musculus	P62331	Pull Down	22522702

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome	17q11 Microdeletion Syndrome
Neurofibromatosis Type 1 Microdeletion Syndrome	Van Asperen Syndrome
Del(17)(Q11)	Monosomy 17q11
Chromosome 17q11.2 Deletion Syndrome, 1.4mb

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11519	RAB11FIP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB11FIP4	VGNC	VGNC:64470
Bos taurus	RAB11FIP4	VGNC	VGNC:33619
Mus musculus	RAB11FIP4	MGD	MGI:2442920
Macaca mulatta	RAB11FIP4	VGNC	VGNC:76571
Canis familiaris	RAB11FIP4	VGNC	VGNC:45251
Rattus norvegicus	RAB11FIP4	RGD	RGD:1305063

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