DHX16 - DEAH-box helicase 16 Gene

Homo sapiens

Also known as DBP2; PRP8; Prp2; DDX16; NMOAS; PRPF2; PRO2014

Gene ID: 8449 | Gene type: protein coding

About DHX16

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,653,127-30,673,006 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 202 orthologues, 18 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 17.0), spleen (RPKM 9.0) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

DHX16 Products(3)

mRNA	Protein	Name
NM_001164239.2	NP_001157711.1	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 2
NM_001363515.2	NP_001350444.1	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 3
NM_003587.5	NP_003578.2	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	35263596	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	35263596	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	35263596	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	35263596	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	29360106	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	20423332	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	29360106	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	35263596	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	20423332	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20423332	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	25296192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX16 Protein Structure

DEAD

Helicase_C

HA2

OB_NTP_bind

0
200
400
600
800
1041 a.a.

Protein Preferred Names

Protein Names

pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

ATP-dependent RNA helicase #3

DHX16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DHX16	O60231	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	22365833
Intra	DHX16	O60231	GPKOW	Homo sapiens	Q92917	Anti Tag CoIP	33961781
Intra	DHX16	O60231	GPKOW	Homo sapiens	Q92917	Anti Tag CoIP	22365833
Intra	DHX16	O60231	SF3B2	Homo sapiens	Q13435	Anti Tag CoIP	22365833
Intra	DHX16	O60231	SF3B2	Homo sapiens	Q13435	Y2H	22365833

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neuromuscular Oculoauditory Syndrome

Neuromuscular Disease And Ocular Or Auditory Anomalies With Or Without Seizures

NMOAS

Plasmodium Malariae Malaria

Quartan Malaria	Malaria By Plasmodium Malariae
Nephrotic Syndrome Of Quartan Malaria	Malaria Nephrosis
Malarial Nephrosis	Nephrotic Syndrome In Malaria
Quartan Nephrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03749	DHX16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DHX16	RGD	RGD:1302963
Bos taurus	DHX16	VGNC	VGNC:28049
Felis catus	DHX16	VGNC	VGNC:61475
Canis familiaris	DHX16	VGNC	VGNC:39940
Macaca mulatta	DHX16	VGNC	VGNC:71761
Mus musculus	DHX16	MGD	MGI:1916442

Name
Email *

	Sorry, but the email address you supplied was invalid.