2. Gene
  3. GPKOW - G-patch domain and KOW motifs Gene

GPKOW - G-patch domain and KOW motifs Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as T54; Mos2; Spp2; GPATC5; GPATCH5

Gene ID: 27238 | Gene type: protein coding

About GPKOW

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,113,407-49,123,735 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

GPKOW Products(1)

mRNA Protein Name
NM_015698.6 NP_056513.2 G-patch domain and KOW motifs-containing protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
21880142 GOA
enables RNA binding IMP
IMP: Inferred from mutant phenotype
25296192 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16491121 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
25296192 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
21880142 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
25296192 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPKOW Protein Structure

G-patch_2

G-patch_2: G-patch domain (146 - 210)

KOW

KOW: KOW motif (243 - 272)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

G-patch domain and KOW motifs-containing protein

G patch domain and KOW motifs-containing protein

GPKOW Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GPKOW Q92917 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
GPKOW Q92917 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
GPKOW Q92917 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra
GPKOW Q92917 CNKSR3 Homo sapiens Q6P9H4
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 CNKSR3 Homo sapiens Q6P9H4
Y2H Array
32296183
Intra
GPKOW Q92917 DHX38 Homo sapiens Q92620
Anti Tag CoIP
22365833
Intra
GPKOW Q92917 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
GPKOW Q92917 HOOK2 Homo sapiens Q96ED9-2
Validated Y2H
32296183
Intra
GPKOW Q92917 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
GPKOW Q92917 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
GPKOW Q92917 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
GPKOW Q92917 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
GPKOW Q92917 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
GPKOW Q92917 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
GPKOW Q92917 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
GPKOW Q92917 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra
GPKOW Q92917 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra
GPKOW Q92917 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
GPKOW Q92917 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
GPKOW Q92917 LRP2BP Homo sapiens Q9P2M1
Y2H Array
32296183
Intra
GPKOW Q92917 LRP2BP Homo sapiens Q9P2M1
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 LRP2BP Homo sapiens Q9P2M1
Validated Y2H
32296183
Intra
GPKOW Q92917 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
GPKOW Q92917 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
GPKOW Q92917 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Y2H Array
31515488
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Anti Tag CoIP
33961781
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Anti Tag CoIP
28514442
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Y2H Array
32296183
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Validated Y2H
25416956
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Validated Y2H
32296183
Intra
GPKOW Q92917 BUD13 Homo sapiens Q9BRD0
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
GPKOW Q92917 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
GPKOW Q92917 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 CCDC57 Homo sapiens Q2TAC2
Y2H Array
25416956
Intra
GPKOW Q92917 ARMCX1 Homo sapiens Q9P291
Y2H Array
32296183
Intra
GPKOW Q92917 ARMCX1 Homo sapiens Q9P291
Validated Y2H
32296183
Intra
GPKOW Q92917 ARMCX1 Homo sapiens Q9P291
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 DHX16 Homo sapiens O60231
Y2H
22365833
Intra
GPKOW Q92917 DHX16 Homo sapiens O60231
Anti Tag CoIP
33961781
Intra
GPKOW Q92917 DHX16 Homo sapiens O60231
Anti Tag CoIP
28514442
Intra
GPKOW Q92917 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra
GPKOW Q92917 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
GPKOW Q92917 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
GPKOW Q92917 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 PRKX Homo sapiens P51817
Y2H
16491121
Intra
GPKOW Q92917 GSTM5 Homo sapiens P46439
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 GSTM5 Homo sapiens P46439
Y2H Array
32296183
Intra
GPKOW Q92917 PRKACB Homo sapiens P22694-2
Y2H
21880142
Intra
GPKOW Q92917 PRKACB Homo sapiens P22694-2
Anti Bait CoIP
21880142
Intra
GPKOW Q92917 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
GPKOW Q92917 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
GPKOW Q92917 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 PHF1 Homo sapiens O43189
Y2H Array
32296183
Intra
GPKOW Q92917 PHF1 Homo sapiens O43189
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra
GPKOW Q92917 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
GPKOW Q92917 SH3GL1 Homo sapiens Q99961
Y2H Array
32296183
Intra
GPKOW Q92917 SH3GL1 Homo sapiens Q99961
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra
GPKOW Q92917 TCEA2 Homo sapiens Q15560
Y2H Prey Pooling
25416956
Intra
GPKOW Q92917 TCEA2 Homo sapiens Q15560
Y2H Array
25416956
Intra
GPKOW Q92917 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
GPKOW Q92917 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 PRPF4 Homo sapiens O43172
Anti Tag CoIP
22365833
Intra
GPKOW Q92917 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
GPKOW Q92917 RBM10 Homo sapiens P98175
Anti Tag CoIP
22365833
Intra
GPKOW Q92917 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
GPKOW Q92917 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
GPKOW Q92917 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
GPKOW Q92917 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
GPKOW Q92917 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
GPKOW Q92917 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
GPKOW Q92917 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
32296183
Intra
GPKOW Q92917 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra
GPKOW Q92917 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
GPKOW Q92917 GMPPA Homo sapiens Q96IJ6
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 GMPPA Homo sapiens Q96IJ6
Validated Y2H
32296183
Intra
GPKOW Q92917 GMPPA Homo sapiens Q96IJ6
Y2H Array
32296183
Intra
GPKOW Q92917 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
GPKOW Q92917 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
GPKOW Q92917 IKBKG Homo sapiens Q9Y6K9
Y2H Array
32296183
Intra
GPKOW Q92917 IKBKG Homo sapiens Q9Y6K9
Validated Y2H
32296183
Intra
GPKOW Q92917 IKBKG Homo sapiens Q9Y6K9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microhydranencephaly, X-Linked

Morse-Rawnsley-Sargent Syndrome

Holoprosencephaly With Fetal Akinesia/Hypokinesia Sequence

MHACX

Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Tarp Syndrome

TARPS

Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot

Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome

Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome

Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome

Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava

Pierre Robin Sequence - Congenital Heart Defect - Talipes

Pierre Robin Syndrome - Congenital Heart Defect - Talipes

Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava

Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Mandibulofacial Dysostosis, Guion-Almeida Type

Mandibulofacial Dysostosis With Microcephaly

Mandibulofacial Dysostosis-Microcephaly Syndrome

MFDGA

MFDM

Mfdm Syndrome

Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate

Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate

Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome

Dysostosis, Mandibulofacial, Guion-Almeida Type
Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome

Brachymelic Primordial Dwarfism

Cephaloskeletal Dysplasia

Low-Birth-Weight Dwarfism With Skeletal Dysplasia

Microcephalic Osteodysplastic Primordial Dwarfism Type I

Osteodysplastic Primordial Dwarfism Type I

Primordial Microcephalic Dwarfism, Crachami Type

Osteodysplastic Primordial Dwarfism, Type 1

MOPD1

Mopd I

Mopd

Osteodysplastic Primordial Dwarfism, Type I

Tals

Microcephalic Osteodysplastic Primordial Dwarfism Type 1

Mopd 1

Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

Mopd Types I And Iii

Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

Primordial Microcephalic Dwarfism Crachami Type

Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05641 GPKOW Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPKOW VGNC VGNC:29535
Macaca mulatta GPKOW VGNC VGNC:73041
Felis catus GPKOW VGNC VGNC:62667
Canis familiaris GPKOW VGNC VGNC:41383
Mus musculus GPKOW MGD MGI:1859610
Rattus norvegicus GPKOW RGD RGD:1583600