USP32 - ubiquitin specific peptidase 32 Gene

Homo sapiens

Also known as USP10; NY-REN-60

Gene ID: 84669 | Gene type: protein coding

About USP32

Cytogenetic location: 17q23.1-q23.2 Genomic coordinates (GRCh38): 17:60,177,327-60,422,416 (from NCBI)

This gene has 15 transcripts (splice variants), 223 orthologues and 71 paralogues. Broad expression in testis (RPKM 36.8), brain (RPKM 14.5) and 23 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Predicted to be involved in protein deubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

USP32 Products(1)

mRNA	Protein	Name
NM_032582.4	NP_115971.2	ubiquitin carboxyl-terminal hydrolase 32

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	20549504	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24705354	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	36476874	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	36476874	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20549504	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP32 Protein Structure

EF-hand_5

DUSP

Ubiquitin_3

UCH

0
300
600
900
1200
1500
1604 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 32

deubiquitinating enzyme 32

USP32 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP32	Q8NFA0	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	USP32	Q8NFA0	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	USP32	Q8NFA0	NME4	Homo sapiens	O00746	Anti Tag CoIP	33961781
Intra	USP32	Q8NFA0	NME4	Homo sapiens	O00746	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Multiple Benign Circumferential Skin Creases On Limbs

Ccsf	Circumferential Skin Creases, Kunze Type
Congenital Circumferential Skin Folds	Kunze-Riehm Syndrome
Kunze Riehm Syndrome	Michelin Tire Baby Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15543	USP32 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP32	RGD	RGD:1306657
Bos taurus	USP32	VGNC	VGNC:36722
Mus musculus	USP32	MGD	MGI:2144475
Canis familiaris	USP32	VGNC	VGNC:48188
Felis catus	USP32	VGNC	VGNC:99569

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