2. Gene
  3. MAP4K3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

MAP4K3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1

Gene ID: 8491 | Gene type: protein coding

About MAP4K3

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:39,249,266-39,437,285 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), testis (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

MAP4K3 Products(7)

mRNA Protein Name
NM_003618.4 NP_003609.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform 1
XM_024453183.2 XP_024308951.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X4
XM_047446093.1 XP_047302049.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X3
NM_001410753.1 NP_001397682.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 3
XM_047446092.1 XP_047302048.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X2
XM_047446091.1 XP_047302047.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X1
NM_001270425.2 NP_001257354.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 2

MAP4K3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 273)

CNH

CNH: CNH domain (567 - 864)

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  • 894 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 3

MAPK/ERK kinase kinase kinase 3

MEK kinase kinase 3

germinal center kinase-like kinase

germinal center kinase-related protein kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-148061 DB1113 99.28% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-RS08077 MAP4K3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08078 Map4k3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08079 Map4k3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP4K3 RGD RGD:621280
Felis catus MAP4K3 VGNC VGNC:81117
Mus musculus MAP4K3 MGD MGI:2154405
Macaca mulatta MAP4K3 VGNC VGNC:81466
Bos taurus MAP4K3 VGNC VGNC:31206
Canis familiaris MAP4K3 VGNC VGNC:42983
Others MAP4K3 NCBI