LTV1 - LTV1 ribosome biogenesis factor Gene

Homo sapiens

Also known as C6orf93; dJ468K18.4

Gene ID: 84946 | Gene type: protein coding

About LTV1

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:143,843,338-143,863,812 (from NCBI)

This gene has 1 transcript (splice variant) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 17.0), testis (RPKM 13.5) and 25 other tissues.

Summary

Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LTV1 Products(2)

mRNA	Protein	Name
NM_001329953.2	NP_001316882.1	protein LTV1 homolog isoform 2
NM_032860.5	NP_116249.2	protein LTV1 homolog isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22113938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTV1 Protein Structure

LTV

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

protein LTV1 homolog

LTV1 homolog

LTV1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LTV1	Q96GA3	BYSL	Homo sapiens	Q13895	Anti Tag CoIP	35271311
Intra	LTV1	Q96GA3	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	LTV1	Q96GA3	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Eumycotic Mycetoma

Eumycetoma	Maduromycosis
Mycetoma	Madura Foot
Maduromycosis, Mycotic	Mycotic Mycetoma
Mycetoma Of Foot	Eumycotic Maduromycosis
Mycetoma Due To Fungal Infection

Dermatomycosis

Dermatomycoses

Cauda Equina Syndrome

Cauda Equina

Polyradiculopathy

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18667	LTV-1	Inhibitor	≥98.0%	Unkown
HY-RS07887	LTV1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LTV1	VGNC	VGNC:102453
Macaca mulatta	LTV1	VGNC	VGNC:83430
Mus musculus	LTV1	MGD	MGI:2447810
Rattus norvegicus	LTV1	RGD	RGD:1311264

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