TRIM5 - tripartite motif containing 5 Gene

Homo sapiens

Also known as RNF88; TRIM5alpha

Gene ID: 85363 | Gene type: protein coding

About TRIM5

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,588,635-5,685,074 (from NCBI)

This gene has 14 transcripts (splice variants), 173 orthologues and 80 paralogues. Ubiquitous expression in urinary bladder (RPKM 5.4), endometrium (RPKM 5.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

TRIM5 Products(8)

mRNA	Protein	Name
NM_001410958.1	NP_001397887.1	tripartite motif-containing protein 5 isoform 4
NM_033034.3	NP_149023.2	tripartite motif-containing protein 5 isoform alpha
NM_033092.4	NP_149083.2	tripartite motif-containing protein 5 isoform gamma
NM_033093.4	NP_149084.2	tripartite motif-containing protein 5 isoform delta
NM_001410958.1	NP_001397887.1	tripartite motif-containing protein 5 isoform 4
NM_033034.3	NP_149023.2	tripartite motif-containing protein 5 isoform alpha
NM_033092.4	NP_149083.2	tripartite motif-containing protein 5 isoform gamma
NM_033093.4	NP_149084.2	tripartite motif-containing protein 5 isoform delta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17156811	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	21512573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12878161	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11331580	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25127057	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	25127057	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	21512573	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	21512573	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	25127057	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	21512573	GOA
involved in regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	25127057	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	12878161	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	GOA
colocalizes with omegasome	IDA IDA: Inferred from direct assay	25127057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM5 Protein Structure

zf-C3HC4_4

zf-B_box

SPRY

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 5

RING-type E3 ubiquitin transferase TRIM5

Recombinant TRIM5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71385	TRIM5 Protein, Human (His)	Q9C035-1 (M1-Q248)	≥95%
HY-P71637	TRIM5 Protein, Human (His, B2M)	Q9C035-1 (M1-S493)	≥95%
HY-P71385A	TRIM5 Protein, Human (N-His)	Q9C035-1 (M1-Q248)	≥95%

Related Diseases

Diseases

Alias

Rubella

German Measles	Three Day Measles
Rubella Nos

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15053	TRIM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM5	RGD	RGD:1304579
Mus musculus	TRIM5	MGD	MGI:3646853
Macaca mulatta	TRIM5	VGNC	VGNC:106441
Others	TRIM5	NCBI

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