2. Gene
  3. NKD1 - NKD inhibitor of WNT signaling pathway 1 Gene

NKD1 - NKD inhibitor of WNT signaling pathway 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Naked1

Gene ID: 85407 | Gene type: protein coding

About NKD1

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,548,396-50,649,249 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 1 paralogue. Broad expression in lung (RPKM 3.1), brain (RPKM 2.1) and 20 other tissues.

Summary

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

NKD1 Products(1)

mRNA Protein Name
NM_033119.5 NP_149110.1 protein naked cuticle homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15687260 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
27846906 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15687260 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15687260 GOA
Cellular Component GO Annotation Evidence Reference Source
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
15687260 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein naked cuticle homolog 1

Dvl-binding protein

NKD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NKD1 Q969G9 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra
NKD1 Q969G9 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
NKD1 Q969G9 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
NKD1 Q969G9 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
NKD1 Q969G9 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
NKD1 Q969G9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
NKD1 Q969G9 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
NKD1 Q969G9 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
NKD1 Q969G9 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
NKD1 Q969G9 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-1
Anti Bait CoIP
16567647
Intra
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-1
Anti Tag CoIP
16567647
Intra
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-2
Anti Tag CoIP
15687260
Intra
NKD1 Q969G9 PPP2R3A Homo sapiens Q06190-2
Anti Tag CoIP
16567647
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09317 NKD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NKD1 RGD RGD:1308491
Macaca mulatta NKD1 VGNC VGNC:75198
Canis familiaris NKD1 VGNC VGNC:43828
Bos taurus NKD1 VGNC VGNC:32093
Mus musculus NKD1 MGD MGI:2135954