NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

Homo sapiens

Also known as Naked2

Gene ID: 85409 | Gene type: protein coding

About NKD2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,008,802-1,038,943 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 194 orthologues and 1 paralogue. Broad expression in lung (RPKM 6.0), skin (RPKM 2.9) and 15 other tissues.

Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

NKD2 Products(2)

mRNA	Protein	Name
NM_001271082.2	NP_001258011.1	protein naked cuticle homolog 2 isoform 2
NM_033120.4	NP_149111.1	protein naked cuticle homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	18504258	GOA
enables growth factor binding	IPI IPI: Inferred from physical interaction	15064403	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	17045239	GOA
enables myosin heavy chain binding	IPI IPI: Inferred from physical interaction	18504258	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15064403	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18757723	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi vesicle fusion to target membrane	IMP IMP: Inferred from mutant phenotype	17553928	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20177058	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15687260	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20177058	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	15064403	GOA
involved in positive regulation of protein processing	IDA IDA: Inferred from direct assay	15064403	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	17553928	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	17553928	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	15064403	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15064403	GOA
located in exocytic vesicle	IDA IDA: Inferred from direct assay	18504258	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	20177058	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18504258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein naked cuticle homolog 2

Dvl-binding protein NKD2

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09318	NKD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKD2	VGNC	VGNC:63814
Rattus norvegicus	NKD2	RGD	RGD:1311459
Macaca mulatta	NKD2	VGNC	VGNC:75199
Mus musculus	NKD2	MGD	MGI:1919543
Bos taurus	NKD2	VGNC	VGNC:59353
Canis familiaris	NKD2	VGNC	VGNC:54105

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