2. Gene
  3. RNF25 - ring finger protein 25 Gene

RNF25 - ring finger protein 25 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AO7

Gene ID: 64320 | Gene type: protein coding

About RNF25

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,663,892-218,672,002 (from NCBI)

This gene has 6 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 11.2), thyroid (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating Enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

RNF25 Products(1)

mRNA Protein Name
NM_022453.3 NP_071898.2 E3 ubiquitin-protein ligase RNF25
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
12748188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18757723 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
26475854 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
12748188 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
27863242 GOA
involved in protein-RNA covalent cross-linking repair IDA
IDA: Inferred from direct assay
37951215 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
27863242 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27863242 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
12748188 GOA
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
27863242 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12748188 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF25 Protein Structure

RWD

RWD: RWD domain (18 - 123)

zf-RING_2

zf-RING_2: Ring finger domain (134 - 202)

  • 0
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  • 200
  • 300
  • 400
  • 459 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF25

RING-type E3 ubiquitin transferase RNF25

RNF25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RNF25 Q96BH1 KCTD21 Homo sapiens Q4G0X4
Y2H Prey Pooling
32296183
Intra
RNF25 Q96BH1 KCTD21 Homo sapiens Q4G0X4
Y2H Array
32296183
Intra
RNF25 Q96BH1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RNF25 Q96BH1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RNF25 Q96BH1 UBE2E2 Homo sapiens Q96LR5
Anti Tag CoIP
33961781
Intra
RNF25 Q96BH1 UBE2D2 Homo sapiens P62837
Anti Tag CoIP
33961781
Intra
RNF25 Q96BH1 UBE2D2 Homo sapiens P62837
Y2H Array
19690564
Intra
RNF25 Q96BH1 UBE2D3 Homo sapiens P61077
Y2H Array
19690564
Intra
RNF25 Q96BH1 UBE2D3 Homo sapiens P61077
Anti Tag CoIP
33961781
Intra
RNF25 Q96BH1 UBE2D3 Homo sapiens P61077
Y2H Array
19549727
Intra
RNF25 Q96BH1 UBE2E3 Homo sapiens Q969T4
Anti Tag CoIP
33961781
Intra
RNF25 Q96BH1 UBE2E3 Homo sapiens Q969T4
Y2H Array
19690564
Intra
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Y2H Array
19690564
Intra
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Y2H Array
19549727
Intra
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Anti Tag CoIP
33961781
Intra
RNF25 Q96BH1 UBE2E1 Homo sapiens P51965
Anti Tag CoIP
28514442
Intra
RNF25 Q96BH1 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra
RNF25 Q96BH1 UBE2D4 Homo sapiens Q9Y2X8
Anti Tag CoIP
33961781
Intra
RNF25 Q96BH1 UBE2D4 Homo sapiens Q9Y2X8
Anti Tag CoIP
28514442
Intra
RNF25 Q96BH1 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
19690564
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypomagnesemia 3, Renal

HOMG3

Renal Hypomagnesemia 3

Fhhnc Without Severe Ocular Involvement

Renal Hypomagnesemia Type 3

Hypomagnesemia, Primary, Due To Defect In Renal Tubular Transport Of Magnesium

Hypomagnesemia, Isolated Renal

Hypomagnesemia, Familial, With Hypercalciuria And Nephrocalcinosis

Familial Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement

Isolated Renal Hypomagnesemia

Primary Hypomagnesemia Due To Defect In Renal Tubular Transport Of Magnesium

Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement

Hypomagnesemia 3

Familial Hypomagnesemia With Hypercalciuria And Nephrocalcinosis

Fhhnc

Hhn

Renal Hypomagnesemia Hypercalciuria Nephrocalcinosis

Hypomagnesemia, Type 3, Renal

Primary Hypomagnesemia
Progesterone-Receptor Positive Breast Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12084 RNF25 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNF25 VGNC VGNC:76736
Bos taurus RNF25 VGNC VGNC:34060
Rattus norvegicus RNF25 RGD RGD:1311557
Felis catus RNF25 VGNC VGNC:64698
Mus musculus RNF25 MGD MGI:1890215
Canis familiaris RNF25 VGNC VGNC:45665