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  3. CDC14B - cell division cycle 14B Gene

CDC14B - cell division cycle 14B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CDC14B3; Cdc14B1; Cdc14B2; hCDC14B

Gene ID: 8555 | Gene type: protein coding

About CDC14B

Cytogenetic location: 9q22.32-q22.33 Genomic coordinates (GRCh38): 9:96,490,939-96,619,843 (from NCBI)

This gene has 13 transcripts (splice variants), 130 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CDC14B Products(7)

mRNA Protein Name
NM_001077181.3 NP_001070649.1 dual specificity protein phosphatase CDC14B isoform 3
NM_001351567.3 NP_001338496.1 dual specificity protein phosphatase CDC14B isoform 4
NM_001351568.3 NP_001338497.1 dual specificity protein phosphatase CDC14B isoform 5
NM_001351569.2 NP_001338498.1 dual specificity protein phosphatase CDC14B isoform 5
NM_001351570.1 NP_001338499.1 dual specificity protein phosphatase CDC14B isoform 6
NM_003671.5 NP_003662.1 dual specificity protein phosphatase CDC14B isoform 1
NM_033331.4 NP_201588.1 dual specificity protein phosphatase CDC14B isoform 2

CDC14B Protein Structure

DSPn

DSPn: Dual specificity protein phosphatase, N-terminal half (52 - 189)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (250 - 360)

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  • 498 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase CDC14B

CDC14 cell division cycle 14 homolog B

Related Diseases

Diseases Alias
Adrenal Gland Pheochromocytoma

Pheochromocytoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161673 CDC14A/B-IN-1 Inhibitor / Unkown
HY-RS02286 CDC14B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDC14B VGNC VGNC:56939
Mus musculus CDC14B MGD MGI:2441808
Macaca mulatta CDC14B VGNC VGNC:103247
Rattus norvegicus CDC14B RGD RGD:1311163
Canis familiaris CDC14B VGNC VGNC:53688