SIRT2 - sirtuin 2 Gene

Homo sapiens

Also known as SIR2; SIR2L; SIR2L2

Gene ID: 22933 | Gene type: protein coding

About SIRT2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,878,555-38,899,618 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 187 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the Sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

SIRT2 Products(7)

mRNA	Protein	Name
NM_001193286.2	NP_001180215.1	NAD-dependent protein deacetylase sirtuin-2 isoform 3
XM_047438469.1	XP_047294425.1	NAD-dependent protein deacetylase sirtuin-2 isoform X3
NM_030593.3	NP_085096.1	NAD-dependent protein deacetylase sirtuin-2 isoform 2
XM_047438468.1	XP_047294424.1	NAD-dependent protein deacetylase sirtuin-2 isoform X1
NR_034146.1
XM_011526655.2	XP_011524957.1	NAD-dependent protein deacetylase sirtuin-2 isoform X2
NM_012237.4	NP_036369.2	NAD-dependent protein deacetylase sirtuin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12887892	GOA
enables NAD+ binding	IDA IDA: Inferred from direct assay	11427894	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	10381378	GOA
enables NAD-dependent histone H4K16 deacetylase activity	IDA IDA: Inferred from direct assay	16648462	GOA
NOT enables NAD-dependent histone deacetylase activity	IDA IDA: Inferred from direct assay	24177535	GOA
enables NAD-dependent histone deacetylase activity	IDA IDA: Inferred from direct assay	11427894	GOA
enables NAD-dependent protein demyristoylase activity	IDA IDA: Inferred from direct assay	25704306	GOA
enables NAD-dependent protein depalmitoylase activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	18722353	GOA
enables NAD-dependent protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	24681946	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	23908241	GOA
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	12887892	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	17488717	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12620231	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12697818	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	17172643	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	23908241	GOA
NOT enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	24177535	GOA
enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	12620231	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	12697818	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11427894	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	24681946	GOA
involved in epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23908241	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12887892	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20543840	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	20543840	GOA
involved in negative regulation of striated muscle tissue development	IDA IDA: Inferred from direct assay	12887892	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18722353	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24681946	GOA
involved in peptidyl-lysine deacetylation	IDA IDA: Inferred from direct assay	23932781	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	23932781	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24681946	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21841822	GOA
NOT involved in protein deacetylation	IDA IDA: Inferred from direct assay	24177535	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	20543840	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	17726514	GOA
NOT involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	24177535	GOA
involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	18722353	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	17726514	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17488717	GOA
located in chromosome	IDA IDA: Inferred from direct assay	16648462	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12697818	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24681946	GOA
located in microtubule	IDA IDA: Inferred from direct assay	12620231	GOA
located in midbody	IDA IDA: Inferred from direct assay	17726514	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	17488717	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15213244	GOA
located in spindle	IDA IDA: Inferred from direct assay	17726514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT2 Protein Structure

SIR2

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacetylase sirtuin-2

NAD-dependent deacetylase sirtuin-2	NAD-dependent protein defatty-acylase sirtuin-2
SIR2-like protein 2	regulatory protein SIR2 homolog 2
silent information regulator 2	sir2-related protein type 2
sirtuin type 2

SIRT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRT2	Q8IXJ6	BUB1B	Homo sapiens	O60566	Anti Bait CoIP	24825348
Intra	SIRT2	Q8IXJ6	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	SIRT2	Q8IXJ6	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	SIRT2	Q8IXJ6	G6PD	Homo sapiens	P11413	Anti Tag CoIP	24769394
Intra	SIRT2	Q8IXJ6	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	12887892
Intra	SIRT2	Q8IXJ6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	21081649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0150	Nicotinamide	Inhibitor	99.99%	Unkown
HY-B0879A	Suramin sodium salt	Inhibitor	99.48%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown
HY-B0150A	Nicotinamide Hydrochloride	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10532	SRT 1720	Activator	99.90%	Unkown
HY-107454	OSS_128167	Inhibitor	98.63%	Unkown
HY-100578	AGK2	Inhibitor	99.62%	Unkown
HY-15145	SRT 1720 monohydrochloride	Activator	99.92%	Unkown
HY-13515	Sirtinol	Inhibitor	≥98.0%	Unkown
HY-101278	Thiomyristoyl	Inhibitor	99.74%	Unkown
HY-100591	SirReal2	Inhibitor	≥99.0%	Unkown
HY-16691	AK-7	Inhibitor	99.93%	Unkown
HY-100732	Cambinol	Inhibitor	99.89%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.33%	Unkown
HY-101073	Salermide	Inhibitor	≥98.0%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.19%	Unkown
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	98.71%	Unkown
HY-N1926	Dihydrocoumarin	Inhibitor	99.81%	Unkown
HY-101465	AK-1	Inhibitor	99.97%	Unkown
HY-146689	SIRT1-IN-2	Inhibitor	98.86%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-107660	SIRT2-IN-8	Inhibitor	99.32%	Unkown
HY-B0150R	Nicotinamide (Standard)	Inhibitor	99.85%	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-112427	Sirt2-IN-1	Inhibitor	98.71%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.58%	Unkown
HY-146690	SIRT1-IN-3	Inhibitor	99.18%	Unkown
HY-147233	MIND4-19	Inhibitor	99.94%	Unkown
HY-148408	SIRT2-IN-11	Inhibitor	99.94%	Unkown
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-111329	JGB1741	Inhibitor	99.05%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-115979	Sirt2-IN-5	Inhibitor	/	Unkown
HY-163532	FLS-359	Modulator	/	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	/	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-145958	Sirt2-IN-6	Inhibitor	/	Unkown
HY-123653	SirReal-1	Inhibitor	/	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-118343	AC-93253	Inhibitor	/	Unkown
HY-149637	HSP70/SIRT2-IN-1	Inhibitor	/	Unkown
HY-W841840	SR94	Inhibitor	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-117442	A2B57	Inhibitor	/	Unkown
HY-119889	A1B11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SIRT2	VGNC	VGNC:34631
Felis catus	SIRT2	VGNC	VGNC:65156
Canis familiaris	SIRT2	VGNC	VGNC:53983
Rattus norvegicus	SIRT2	RGD	RGD:621481
Macaca mulatta	SIRT2	VGNC	VGNC:77219
Mus musculus	SIRT2	MGD	MGI:1927664
Others	SIRT2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.