PSMG1 - proteasome assembly chaperone 1 Gene

Homo sapiens

Also known as PAC1; DSCR2; PAC-1; C21LRP; LRPC21

Gene ID: 8624 | Gene type: protein coding

About PSMG1

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,174,769-39,183,514 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Broad expression in testis (RPKM 57.7), thyroid (RPKM 14.4) and 23 other tissues.

Summary

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]

PSMG1 Products(4)

mRNA	Protein	Name
NM_001261824.1	NP_001248753.1	proteasome assembly chaperone 1 isoform 3
NM_001320795.1	NP_001307724.1	proteasome assembly chaperone 1 isoform d
NM_003720.4	NP_003711.1	proteasome assembly chaperone 1 isoform a
NM_203433.2	NP_982257.1	proteasome assembly chaperone 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	16251969	GOA
enables molecular adaptor activity	IGI IGI: Inferred from genetic interaction	17189198	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16251969	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated protein complex assembly	IDA IDA: Inferred from direct assay	16251969	GOA
involved in chaperone-mediated protein complex assembly	IGI IGI: Inferred from genetic interaction	17189198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15670775	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15590417	GOA
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	16251969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proteasome assembly chaperone 1

Down syndrome critical region gene 2

PSMG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMG1	O95456	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	PSMG1	O95456	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	PSMG1	O95456	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	PSMG1	O95456	PSMG2	Homo sapiens	Q969U7	Y2H Fragment Pooling	35914814
Intra	PSMG1	O95456	PSMG2	Homo sapiens	Q969U7	Y2H Prey Pooling	32296183
Intra	PSMG1	O95456	PSMG2	Homo sapiens	Q969U7	Validated Y2H	32296183
Intra	PSMG1	O95456	PSMG2	Homo sapiens	Q969U7	Anti Tag CoIP	35271311
Intra	PSMG1	O95456	PSMG2	Homo sapiens	Q969U7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Thrombasthenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11336	PSMG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMG1	RGD	RGD:1305454
Bos taurus	PSMG1	VGNC	VGNC:33478
Mus musculus	PSMG1	MGD	MGI:1860263
Macaca mulatta	PSMG1	VGNC	VGNC:76347
Canis familiaris	PSMG1	VGNC	VGNC:45121
Felis catus	PSMG1	VGNC	VGNC:102810

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