PSMG2 - proteasome assembly chaperone 2 Gene

Homo sapiens

Also known as PAC2; HCCA3; CLAST3; MDS003; PRAAS4; HsT1707; TNFSF5IP1

Gene ID: 56984 | Gene type: protein coding

About PSMG2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,658,738-12,725,740 (from NCBI)

This gene has 23 transcripts (splice variants), 218 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 46.4), bone marrow (RPKM 28.3) and 25 other tissues.

Summary

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in nucleus. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]

PSMG2 Products(2)

mRNA	Protein	Name
NM_020232.5	NP_064617.2	proteasome assembly chaperone 2 isoform 1
NM_147163.2	NP_671692.1	proteasome assembly chaperone 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IGI IGI: Inferred from genetic interaction	17189198	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16251969	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated protein complex assembly	IDA IDA: Inferred from direct assay	16251969	GOA
involved in chaperone-mediated protein complex assembly	IGI IGI: Inferred from genetic interaction	17189198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	16251969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMG2 Protein Structure

PAC2

0
100
200
264 a.a.

Protein Preferred Names

Protein Names

proteasome assembly chaperone 2

CD40 ligand-activated specific transcript 3

PSMG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMG2	Q969U7	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	PSMG2	Q969U7	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	PSMG2	Q969U7	PSMG1	Homo sapiens	O95456	Anti Tag CoIP	33961781
Intra	PSMG2	Q969U7	PSMG1	Homo sapiens	O95456	Y2H Prey Pooling	32296183
Intra	PSMG2	Q969U7	PSMG1	Homo sapiens	O95456	Anti Tag CoIP	35271311
Intra	PSMG2	Q969U7	PSMG1	Homo sapiens	O95456	Y2H Array	32296183
Intra	PSMG2	Q969U7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	PSMG2	Q969U7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	PSMG2	Q969U7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	PSMG2	Q969U7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	PSMG2	Q969U7	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	PSMG2	Q969U7	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Proteasome-Associated Autoinflammatory Syndrome 4

PRAAS4

Panniculitis

Nodular Panniculitis

Proteasome-Associated Autoinflammatory Syndrome

Aldd Syndrome	Autoinflammation-Lipodystrophy-Dermatosis Syndrome
Praas	Proteasome Disability Syndrome

Solitary Median Maxillary Central Incisor

SMMCI	Fused Incisors
Single Upper Central Incisor	Single Central Maxillary Incisor
Single Median Maxillary Central Incisor	Solitary Median Maxillary Central Incisor Syndrome
Incisors Fused	Incisors, Fused

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Basal Ganglia Calcification

Fahr'S Syndrome	Fahr'S Disease
Fahr Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11337	PSMG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PSMG2	VGNC	VGNC:33479
Rattus norvegicus	PSMG2	RGD	RGD:1304867
Mus musculus	PSMG2	MGD	MGI:1922901
Felis catus	PSMG2	VGNC	VGNC:107719
Canis familiaris	PSMG2	VGNC	VGNC:45122

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