UNC5C - unc-5 netrin receptor C Gene

Homo sapiens

Also known as UNC5H3

Gene ID: 8633 | Gene type: protein coding

About UNC5C

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:95,162,504-95,548,973 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues.

Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for Others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

UNC5C Products(1)

mRNA	Protein	Name
NM_003728.4	NP_003719.3	netrin receptor UNC5C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22685302	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	27068745	GOA
enables tubulin binding	IPI IPI: Inferred from physical interaction	28483977	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dorsal root ganglion development	IDA IDA: Inferred from direct assay	28483977	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	25419706	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC5C Protein Structure

I-set

TSP_1

ZU5

Death

0
200
400
600
800
931 a.a.

Protein Preferred Names

Protein Names

netrin receptor UNC5C

protein unc-5 homolog 3

UNC5C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UNC5C	O95185	TUBB3	Homo sapiens	Q13509	Pull Down	28483977
Intra	UNC5C	O95185	TUBB3	Homo sapiens	Q13509	Anti Tag CoIP	28483977

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Immunodeficiency 43

Hypoproteinemia, Hypercatabolic	IMD43
Beta-2-Microglobulin Deficiency	B2m Deficiency
Hypercatabolic Hypoproteinemia

Glass Syndrome

Chromosome 2q32-Q33 Deletion Syndrome	Satb2-Associated Syndrome
2q33.1 Microdeletion Syndrome	Sas
2q32-Q33 Microdeletion Syndrome	2q32q33 Microdeletion Syndrome
Monosomy 2q32	Monosomy 2q32-Q33
Monosomy 2q32q33	2q32 Deletion Syndrome
Del(2)(Q32)	Del(2)(Q32q33)
GLASS	2q32q33 Microdeletion Syndromes
Satb2 Syndrome	Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Del(2)(Q33.1)	Monosomy 2q33.1
Satb2-Associated Syndrome Due To A Pathogenic Variant	Satb2-Associated Syndrome Due To A Point Mutation
Satb2 Associated Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3882	Fmoc-Ala-Glu-Gln-Lys-NH2		99.90%	Unkown
HY-RS15473	UNC5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UNC5C	VGNC	VGNC:66830
Macaca mulatta	UNC5C	VGNC	VGNC:78723
Bos taurus	UNC5C	VGNC	VGNC:36672
Mus musculus	UNC5C	MGD	MGI:1095412
Rattus norvegicus	UNC5C	RGD	RGD:735109
Canis familiaris	UNC5C	VGNC	VGNC:48141

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