OASL - 2'-5'-oligoadenylate synthetase like Gene

Homo sapiens

Also known as OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL

Gene ID: 8638 | Gene type: protein coding

About OASL

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,017,761-121,039,246 (from NCBI)

This gene has 11 transcripts (splice variants), 123 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues.

Summary

Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OASL Products(5)

mRNA	Protein	Name
NM_001261825.2	NP_001248754.1	2'-5'-oligoadenylate synthase-like protein isoform c
NM_001395418.1	NP_001382347.1	2'-5'-oligoadenylate synthase-like protein isoform b
NM_001395419.1	NP_001382348.1	2'-5'-oligoadenylate synthase-like protein isoform d
NM_003733.4	NP_003724.1	2'-5'-oligoadenylate synthase-like protein isoform a
NM_198213.3	NP_937856.1	2'-5'-oligoadenylate synthase-like protein isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables 2'-5'-oligoadenylate synthetase activity	IDA IDA: Inferred from direct assay	9826176	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	9826176	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	9826176	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30833792	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in interleukin-27-mediated signaling pathway	IEP IEP: Inferred from expression pattern	32270034	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	18931074	GOA
involved in positive regulation of RIG-I signaling pathway	IDA IDA: Inferred from direct assay	25925578	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	18931074	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9826176	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9826176	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OASL Protein Structure

OAS1_C

ubiquitin

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

2'-5'-oligoadenylate synthase-like protein

2'-5'-OAS-RP

OASL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OASL	Q15646	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	OASL	Q15646	LARP7	Homo sapiens	Q4G0J3	Pull Down	30833792

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

West Nile Fever

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09730	OASL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OASL	VGNC	VGNC:32392
Canis familiaris	OASL	VGNC	VGNC:44089
Mus musculus	OASL	MGD	MGI:2180849
Rattus norvegicus	OASL	RGD	RGD:1308586
Macaca mulatta	OASL	VGNC	VGNC:75572

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