RNGTT - RNA guanylyltransferase and 5'-phosphatase Gene

Homo sapiens

Also known as HCE; HCE1; hCAP; CAP1A

Gene ID: 8732 | Gene type: protein coding

About RNGTT

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:88,609,897-88,963,618 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 8.1), testis (RPKM 5.3) and 24 other tissues.

Summary

Enables mRNA guanylyltransferase activity and triphosphatase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNGTT Products(3)

mRNA	Protein	Name
NM_001286426.2	NP_001273355.1	mRNA-capping enzyme isoform b
NM_001286428.2	NP_001273357.1	mRNA-capping enzyme isoform c
NM_003800.5	NP_003791.3	mRNA-capping enzyme isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA guanylyltransferase activity	IDA IDA: Inferred from direct assay	21636784	GOA
enables inorganic triphosphate phosphatase activity	IDA IDA: Inferred from direct assay	9473487	GOA
enables mRNA guanylyltransferase activity	IDA IDA: Inferred from direct assay	9473487	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25137142	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 7-methylguanosine mRNA capping	IDA IDA: Inferred from direct assay	9473487	GOA
involved in RNA processing	IDA IDA: Inferred from direct assay	21636784	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNGTT Protein Structure

DSPc

mRNA_cap_enzyme

mRNA_cap_C

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

mRNA-capping enzyme

HCAP1

RNGTT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNGTT	O60942	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	RNGTT	O60942	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	RNGTT	O60942	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RNGTT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83214	HCE Antibody (YA2959)	WB, ICC/IF, IP	Human, Rat

Related Diseases

Diseases

Alias

Cecum Carcinoma

Cecum Cancer	Caecum Carcinoma
Carcinoma Of Cecum	Cecal Cancer
Malignant Neoplasm Of Caecum	Malignant Tumor Of The Cecum

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Photokeratitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12099	RNGTT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNGTT	VGNC	VGNC:76709
Felis catus	RNGTT	VGNC	VGNC:102508
Rattus norvegicus	RNGTT	RGD	RGD:1311410
Bos taurus	RNGTT	VGNC	VGNC:34076
Canis familiaris	RNGTT	VGNC	VGNC:45679
Mus musculus	RNGTT	MGD	MGI:1329041

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