HRK - harakiri, BCL2 interacting protein Gene

Homo sapiens

Also known as DP5; HARAKIRI

Gene ID: 8739 | Gene type: protein coding

About HRK

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:116,856,144-116,881,441 (from NCBI)

This gene has 4 transcripts (splice variants) and 54 orthologues. Biased expression in brain (RPKM 5.1), thyroid (RPKM 2.9) and 3 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. Members of this family are involved in activating or inhibiting Apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes Apoptosis by interacting with the apoptotic inhibitors Bcl-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

HRK Products(1)

mRNA	Protein	Name
NM_003806.4	NP_003797.1	activator of apoptosis harakiri

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14596824	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15031724	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	21041309	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	21041309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	15031724	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HRK Protein Structure

Harakiri

0
91 a.a.

Protein Preferred Names

Protein Names

activator of apoptosis harakiri

BH3-interacting domain-containing protein 3

Related Diseases

Diseases

Alias

Chronic Gonococcal Salpingitis

Gonococcal Salpingitis

Cycloplegia

Ciliary Muscle Paresis	Cycloplegic Paralysis Of Accommodation
Paresis Of Accommodation	Visual Accommodation Paralysis
Accommodation Paralysis	Intrinsic Paralysis Of Eye Muscle
Cycloplegic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5342	Hrk BH3		/	Unkown
HY-RS06371	HRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HRK	VGNC	VGNC:107709
Mus musculus	HRK	MGD	MGI:1201608
Rattus norvegicus	HRK	RGD	RGD:70549
Canis familiaris	HRK	VGNC	VGNC:41789
Bos taurus	HRK	VGNC	VGNC:29957

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