PABPC4 - poly(A) binding protein cytoplasmic 4 Gene

Homo sapiens

Also known as APP1; APP-1; PABP4; iPABP

Gene ID: 8761 | Gene type: protein coding

About PABPC4

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:39,560,816-39,576,790 (from NCBI)

This gene has 42 transcripts (splice variants), 219 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 55.5), ovary (RPKM 46.1) and 25 other tissues.

Summary

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]

PABPC4 Products(3)

mRNA	Protein	Name
NM_001135653.2	NP_001129125.1	polyadenylate-binding protein 4 isoform 1
NM_001135654.2	NP_001129126.1	polyadenylate-binding protein 4 isoform 3
NM_003819.4	NP_003810.1	polyadenylate-binding protein 4 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables poly(A) binding	IDA IDA: Inferred from direct assay	8524242	GOA
NOT enables poly(C) RNA binding	IDA IDA: Inferred from direct assay	8524242	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	8524242	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11369516	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8524242	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	21940797	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21940797	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PABPC4 Protein Structure

RRM_1

PABP

0
100
200
300
400
500
600
644 a.a.

Protein Preferred Names

Protein Names

polyadenylate-binding protein 4

PABP-4

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 5

DFNA5	Autosomal Dominant Nonsyndromic Deafness 5
Autosomal Dominant Deafness 5	Deafness, Autosomal Dominant, 5
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 5	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 5
Deafness, Autosomal Dominant, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09950	PABPC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09951	PABPC4L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PABPC4	VGNC	VGNC:55644
Macaca mulatta	PABPC4	VGNC	VGNC:100023
Rattus norvegicus	PABPC4	RGD	RGD:1305015
Mus musculus	PABPC4	MGD	MGI:2385206

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