PHLDA1 - pleckstrin homology like domain family A member 1 Gene

Homo sapiens

Also known as PHRIP; TDAG51; DT1P1B11

Gene ID: 22822 | Gene type: protein coding

About PHLDA1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,025,447-76,031,776 (from NCBI)

This gene has 3 transcripts (splice variants), 172 orthologues and 2 paralogues. Ubiquitous expression in salivary gland (RPKM 37.9), liver (RPKM 29.7) and 25 other tissues.

Summary

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

PHLDA1 Products(1)

mRNA	Protein	Name
NM_007350.3	NP_031376.3	pleckstrin homology-like domain family A member 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11369516	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pleckstrin homology-like domain family A member 1

PQ-rich protein

PHLDA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PHLDA1	Q8WV24	EIF3D	Homo sapiens	O15371	Y2H	11369516
Intra	PHLDA1	Q8WV24	EIF3D	Homo sapiens	O15371	Pull Down	11369516
Intra	PHLDA1	Q8WV24	PABPC4	Homo sapiens	Q13310	Pull Down	11369516
Intra	PHLDA1	Q8WV24	MDFI	Homo sapiens	Q99750	Y2H Array	19060904
Intra	PHLDA1	Q8WV24	MDFI	Homo sapiens	Q99750	Y2H Pooling	19060904

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Syringoma

Microcystic Adnexal Carcinoma	Microcystic Adnexal Carcinoma Of Skin
Syringomatous Carcinoma	Eccrine Epithelioma

Fibroepithelial Basal Cell Carcinoma

Fibroepithelioma Of Pinkus	Fibroepithelioma Of Pinkus Type
Pinkus Tumor

Inverted Follicular Keratosis

Inverted Folicular Keratosis

Seborrheic Keratosis

Malignant Acrospiroma

Eccrine Ductal Carcinoma	Hidradenocarcinoma
Anaplastic Syringoma	Eccrine Ductal Carcinoma Of Skin
Clear Cell Eccrine Carcinoma	Malignant Clear Cell Acrospiroma
Malignant Nodular/Clear Cell Hidradenoma	Primary Mucoepidermoid Cutaneous Carcinoma
Sweat Gland Adenocarcinoma

Follicular Infundibulum Tumor

Tumor Of Follicular Infundibulum	Follicular Infundibulum Tumour
Neoplasm Of The Follicular Infundibulum	Tumour Of Follicular Infundibulum

Morpheaform Basal Cell Carcinoma

Basal Cell Carcinoma, Morphea	Cicatricial Basal-Cell Carcinoma
Morphea-Type Basal Cell Carcinoma	Morpheic Basal Cell Carcinoma

Clear Cell Basal Cell Carcinoma

Skin Clear Cell Basal Cell Carcinoma

Basal Cell Carcinoma, Infundibulocystic

Basal Cell Carcinoma With Follicular Differentiation	Infundibulocystic Basal Cell Carcinoma
Skin Infundibulocystic Basal Cell Carcinoma

Pilar Sheath Acanthoma

Acanthoma, Pilar Sheath

Aggressive Digital Papillary Adenocarcinoma

Epidermal Appendage Tumor

Neoplasm Of Skin With Adnexal Differentiation	Neoplasm Of The Skin Appendage
Skin Appendage Tumour

Squamous Papillomatosis

Eccrine Sweat Gland Cancer

Malignant Eccrine Skin Neoplasm

Malignant Eccrine Tumor

Sweat Gland Cancer

Sweat Gland Carcinoma	Malignant Neoplasm Of Sweat Gland
Malignant Tumor Of The Sweat Gland	Carcinoma Of The Sweat Gland
Primary Malignant Neoplasm Of Sweat Gland	Sweat Gland Neoplasms

Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour

Syringocystadenoma Papilliferum

Fistulous Vegetative Verrucous Hydradenoma	Papillary Syringadenoma
Naevus Syringocystadenomatosus Papilliferus	Papillary Syringocystadenoma
Scap	Syringadenoma Papilliferum
Papillary Hidradenoma

Acanthoma

Hidrocystoma

Apocrine Cystadenoma	Eccrine Hidrocystoma
Eccrine Cystadenoma	Eccrine Hidrocystoma Of Skin
Apocrine Adenoma

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Hidradenoma

Adenoma, Sweat Gland	Hidradenoma Of Skin
Sweat Gland Adenoma	Syringoadenoma
Eccrine Acrospiroma	Benign Neoplasm Of Sweat Gland

Eccrine Papillary Adenocarcinoma

Digital Papillary Adenocarcinoma	Sweat Gland Adenocarcinoma
Digital Papillary Eccrine Carcinoma Of Skin

Basosquamous Carcinoma

Carcinoma, Basosquamous	Basisquamous Cell Carcinoma
Basosquamous Cell Carcinoma	Metatypical Carcinoma

Pilomatrixoma

Pilomatricoma	PTR
Epithelioma Calcificans Of Malherbe	Benign Pilomatricoma
Calcifying Epithelioma Of Malherbe	Pilomatricoma, Somatic
Benign Pilomatrixoma	Malherbe Calcifying Epithelioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10442	PHLDA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHLDA1	VGNC	VGNC:68830
Rattus norvegicus	PHLDA1	RGD	RGD:3836
Mus musculus	PHLDA1	MGD	MGI:1096880
Bos taurus	PHLDA1	VGNC	VGNC:32835
Canis familiaris	PHLDA1	VGNC	VGNC:44501

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