TNFRSF18 - TNF receptor superfamily member 18 Gene

Homo sapiens

Also known as AITR; GITR; CD357; GITR-D; ENERGEN

Gene ID: 8784 | Gene type: protein coding

About TNFRSF18

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,203,508-1,206,592 (from NCBI)

This gene has 4 transcripts (splice variants), 562 orthologues and 21 paralogues. Biased expression in skin (RPKM 4.0), appendix (RPKM 1.0) and 12 other tissues.

Summary

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

TNFRSF18 Products(3)

mRNA	Protein	Name
NM_004195.3	NP_004186.1	tumor necrosis factor receptor superfamily member 18 isoform 1 precursor
NM_148901.2	NP_683699.1	tumor necrosis factor receptor superfamily member 18 isoform 2 precursor
NM_148902.2	NP_683700.1	tumor necrosis factor receptor superfamily member 18 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18040044	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23892569	GOA
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	23892569	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23892569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 18

TNF receptor superfamily activation-inducible protein

TNFRSF18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNFRSF18	Q9Y5U5	TNFSF18	Homo sapiens	Q9UNG2	SPR	18378892

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70683	GITR Protein, Human (HEK293, hFc)	Q9Y5U5 (Q26-E161)	≥95%
HY-P70822	GITR Protein, Human (T45A, HEK293, mFc)	Q9Y5U5 (Q26-E161, T45A)	≥95%
HY-P73076	GITR Protein, Human (HEK293, His)	Q9Y5U5 (Q26-E161)	≥95%
HY-P75166	GITR Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9Y5U5 (Q26-E161)	≥95%
HY-P78137	GITR Protein, Human (Biotinylated, HEK293, His-Avi)	Q9Y5U5 (Q26-E161)	≥95%

TNFRSF18 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81588	GITR Antibody (YA1333)	FC, ELISA	Human

Related Diseases

Diseases

Alias

Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked

IPEX	X-Linked Autoimmunity-Allergic Dysregulation Syndrome
Xlaad	Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked
Ipex Syndrome	Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome
Iddm-Secretory Diarrhea Syndrome	Dmsd
Autoimmunity-Immunodeficiency Syndrome, X-Linked	Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy
Xpid	Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked
Autoimmune Enteropathy Type 1	Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked
Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly	Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome
Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked	Autoimmunity-Immunodeficiency Syndrome X-Linked
Iddm Secretory Diarrhea Syndrome	Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked
Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome	Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome
X-Linked Autoimmunity-Immunodeficiency Syndrome	Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome
X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea

Diverticulitis

Immunodeficiency 41 With Lymphoproliferation And Autoimmunity

Cd25 Deficiency	Immunodeficiency Due To Cd25 Deficiency
IMD41	Interleukin 2 Receptor, Alpha, Deficiency Of
Il2ra Deficiency	Immunodeficiency 41
Interleukin-2 Receptor Alpha Chain Deficiency	Interleukin 2 Receptor Alpha Deficiency
Interleukin-2 Receptor, Alpha Chain, Deficiency Of	Immunodeficiency, Type 41 With Lymphoproliferation And Autoimmunity

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14808	TNFRSF18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF18	MGD	MGI:894675
Macaca mulatta	TNFRSF18	VGNC	VGNC:78587
Rattus norvegicus	TNFRSF18	RGD	RGD:1565872
Canis familiaris	TNFRSF18	VGNC	VGNC:47660
Felis catus	TNFRSF18	VGNC	VGNC:66406
Bos taurus	TNFRSF18	VGNC	VGNC:36163
Macaca fascicularis	TNFRSF18	NCBI	NCBI:102146362
Others	TNFRSF18	NCBI

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