DYRK4 - dual specificity tyrosine phosphorylation regulated kinase 4 Gene

Homo sapiens

Gene ID: 8798 | Gene type: protein coding

About DYRK4

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,562,208-4,613,875 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 12 paralogues. Broad expression in testis (RPKM 18.7), thyroid (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes an Enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

DYRK4 Products(7)

mRNA	Protein	Name
NM_001282285.3	NP_001269214.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 2
NM_001282286.2	NP_001269215.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 3
NM_001371301.2	NP_001358230.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 4
NM_001394779.1	NP_001381708.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 5
NM_001394780.1	NP_001381709.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 6
NM_001407019.1	NP_001393948.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1
NM_003845.3	NP_003836.1	dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK4 Protein Structure

Pkinase

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 4

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

Abdominal Obesity-Metabolic Syndrome 3

AOMS3	Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease
Obesity, Abdominal, Metabolic Syndrome, Type 3

Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome	Abdominal Obesity Metabolic Syndrome
Metabolic Syndrome X	Aoms2
Aoms1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-162750	ZJCK-6-46	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYRK4	MGD	MGI:1330292
Macaca mulatta	DYRK4	VGNC	VGNC:97761
Bos taurus	DYRK4	VGNC	VGNC:55903
Felis catus	DYRK4	VGNC	VGNC:83870
Rattus norvegicus	DYRK4	RGD	RGD:1306800
Others	DYRK4	NCBI

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