KSR1 - kinase suppressor of ras 1 Gene

Homo sapiens

Also known as KSR; RSU2

Gene ID: 8844 | Gene type: protein coding

About KSR1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,456,448-27,626,435 (from NCBI)

This gene has 20 transcripts (splice variants), 272 orthologues and 23 paralogues. Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues.

Summary

Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

KSR1 Products(5)

mRNA	Protein	Name
NM_001367810.1	NP_001354739.1	kinase suppressor of Ras 1 isoform 2
NM_001394583.1	NP_001381512.1	kinase suppressor of Ras 1 isoform 3
NM_001394584.1	NP_001381513.1	kinase suppressor of Ras 1 isoform 4
NM_001394585.1	NP_001381514.1	kinase suppressor of Ras 1 isoform 5
NM_014238.2	NP_055053.1	kinase suppressor of Ras 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	29433126	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	29433126	GOA
enables protein binding	IDA IDA: Inferred from direct assay	22572157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11909642	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	29433126	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22572157	GOA
located in membrane	IDA IDA: Inferred from direct assay	22572157	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22572157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KSR1 Protein Structure

Pkinase_Tyr

0
200
400
600
762 a.a.

Protein Preferred Names

Protein Names

kinase suppressor of Ras 1

KSR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KSR1	Q8IVT5	MAP2K2	Homo sapiens	P36507	Y2H	11909642
Intra	KSR1	Q8IVT5	MAP2K2	Homo sapiens	P36507	Anti Tag CoIP	27086506

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07475	KSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KSR1	VGNC	VGNC:74221
Bos taurus	KSR1	VGNC	VGNC:30754
Felis catus	KSR1	VGNC	VGNC:97479
Mus musculus	KSR1	MGD	MGI:105051
Rattus norvegicus	KSR1	RGD	RGD:1308105
Canis familiaris	KSR1	VGNC	VGNC:42547

Name
Email *

	Sorry, but the email address you supplied was invalid.